ATR Cancer Research Results

ATR, Ataxia-Telangiectasia and Rad3-related: Click to Expand ⟱
Source:
Type:
ATR (Ataxia-Telangiectasia and Rad3-related) is a serine/threonine kinase that plays a crucial role in maintaining genome stability and preventing cancer.

ATR is a protein kinase that is activated in response to DNA damage, particularly replication stress and single-strand breaks. When DNA damage occurs, ATR is activated and phosphorylates a variety of downstream targets, including Chk1, p53, and BRCA1. This activation of ATR triggers a signaling cascade that leads to cell cycle arrest, DNA repair, and apoptosis (programmed cell death) if the damage is too severe to be repaired.
ATR is frequently overexpressed in cancers, and its expression is associated with a more aggressive disease and poorer outcomes.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1/CCNA1↑, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Chk2↑, 1,   CK2↓, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   ATR↑, 1,   CHK1↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycA1/CCNA1↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATR, Ataxia-Telangiectasia and Rad3-related
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:717  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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