GranB Cancer Research Results

GranB, Granzyme B: Click to Expand ⟱
Source:
Type: serine protease
Granzyme B is a serine protease that is expressed by cytotoxic T cells and natural killer cells, and plays a crucial role in the immune system's ability to eliminate infected cells and tumor cells. Granzyme B works in conjunction with perforin to induce apoptosis (programmed cell death) in target cells.

In the context of cancer, granzyme B has been found to have both positive and negative effects.

Granzyme B is an important marker of immune activity in the tumor microenvironment, and its expression is often associated with better prognosis in various cancers. High levels of Granzyme B in tumor-infiltrating lymphocytes indicate an effective anti-tumor immune response, which can help control tumor growth and improve patient outcomes.


Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
1281- SK,    Enhancement of NK cells proliferation and function by Shikonin
- in-vivo, Colon, Caco-2
Perforin↑, GranB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↑, 1,   GranB↑, 1,   Perforin↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Immune & Inflammatory Signaling ⓘ

NK cell↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GranB, Granzyme B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:872  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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