SESN2 Cancer Research Results

SESN2, Sestrin 2: Click to Expand ⟱
Source:
Type:
Sestrin 2 (SESN2) is a protein that plays a crucial role in regulating cellular metabolism, stress response, and apoptosis.
High SESN2 expression is associated with better prognosis, including increased overall survival and reduced recurrence.
Low SESN2 expression is associated with poor prognosis, including increased tumor size, stage, and metastasis.
SESN2 encodes Sestrin-2, a conserved stress-inducible protein activated by oxidative stress, DNA damage, hypoxia, and nutrient deprivation (often downstream of p53/ATF4). Its core biochemical role is to restrain growth during stress.

Key functions
-Inhibits mTORC1 (via AMPK/TSC and GATOR pathways)
-Promotes autophagy
-Reduces ROS and restores redox balance
-Coordinates metabolic slowdown during damage


Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
7921- VT,    Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches
- in-vitro, Colon, Caco-2
Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   MDA↑, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   BAX↓, 1,   PUMA↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

SESN2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PI3K↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SESN2, Sestrin 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:919  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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