MKP1 Cancer Research Results

MKP1, MAP kinase phosphatase 1: Click to Expand ⟱
Source:
Type:
MKP-1 and MKP-2 belong to the dual-specificity phosphatase family and are key regulators of MAPK signaling pathways (including ERK, JNK, and p38), which are central to cell proliferation, differentiation, and apoptosis.
-By dephosphorylating MAPKs, these phosphatases help maintain signaling homeostasis and protect cells against excessive or prolonged MAPK activation that could lead to cell death or uncontrolled proliferation.

-MKP-1 is frequently upregulated in various cancers, including breast, lung, and ovarian cancers, where it may serve as a feedback inhibitor of MAPK pathways.
- In some studies, high MKP-1 levels have been linked to resistance to chemotherapy and radiotherapy, as enhanced deactivation of MAPKs can reduce apoptosis in response to treatment-induced stress.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
4508- GLA,  aLinA,    α-Linolenic and γ-linolenic acids exercise differential antitumor effects on HT-29 human colorectal cancer cells
- in-vitro, Colon, HT29
Apoptosis↑, *Inflam↓, AntiCan↑, lipid-P↑, COX2↝, MKP1↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   MKP1↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: MKP1, MAP kinase phosphatase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:1225  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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