SVCT-2 Cancer Research Results

SVCT-2, Sodium-dependent Vitamin C Transporter 2: Click to Expand ⟱
Source:
Type:
SVCT-2 is a protein that plays a role in the transport of vitamin C (ascorbic acid) into cells.
SVCT-2 is expressed in: 70% breast, 60% lung, 80% CRC, 50% Prostate, 70% ovarian, 60% Pancreatic, 50% liver, 60% stomach, 50% esophageal, 60% Head and Neck, 50% Melanoma, 70% GBM, 60% Medulloblastoma.
SVCT-2 was involved in the transport of vitamin C into lung cancer cells and that its inhibition reduced cancer cell growth and survival.
Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
Scientific Papers found: Click to Expand⟱
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF-7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

NAD↓, 1,  

Cell Death ⓘ

proCasp3↑, 1,   TumCD↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Barriers & Transport ⓘ

SVCT-2↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SVCT-2, Sodium-dependent Vitamin C Transporter 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:31  Cells:%  prod#:%  Target#:814  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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