cycE1 Cancer Research Results

cycE1, cyclin E1(CCNE1): Click to Expand ⟱

Source:

Type: protein

Cyclin E1 is a protein that plays a crucial role in the regulation of the cell cycle, particularly during the G1 phase. It is a member of the cyclin family, which are proteins that bind to and activate cyclin-dependent kinases (CDKs). The cyclin E1-CDK2 complex is essential for the progression of cells from the G1 phase to the S phase, where DNA replication occurs.

In cancer, cyclin E1 has been found to be overexpressed in various types of tumors, including breast, ovarian, and lung cancers. This overexpression can lead to uncontrolled cell proliferation, a hallmark of cancer.

Bladder, Bladder Cancer: Click to Expand ⟱

Bladder Cancer

Scientific Papers found: Click to Expand⟱

459-

CUR,

Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells

in-vitro,

Bladder,

T24/HTB-9

10, 15, 20 and 25 µM, 48 and 72 h

in-vitro,

Bladder,

RT4

Trop2↓, Apoptosis↑, cycE1↓, p27↑, TumCCA↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, p27↑, 1,

Cell Cycle & Senescence ⓘ

cycE1↓, 1, TumCCA↑, 1,

Migration ⓘ

Trop2↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: cycE1, cyclin E1(CCNE1)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells