CLDN1 Cancer Research Results

CLDN1, claudin-1: Click to Expand ⟱
Source:
Type: gene
The CLDN1 gene (Claudin-1) is a tight junction protein that plays a crucial role in maintaining epithelial barrier function and regulating cell-cell adhesion.

Breast cancer: Elevated in 50% of breast cancer, associated with poor prognosis
Lung cancer: Elevated in 60% of lung cancer tissues, associated with poor prognosis
Colorectal cancer: Elevated in 70%, associated with poor prognosis
Prostate cancer: REDUCED in 40%, and associated with poor prognosis
Ovarian cancer: Elevated in 55%, associated with poor prognosis
Gastric cancer:Elevated in 60%, associated with poor prognosis
Hepatocellular carcinoma:Elevated in 65%, associated with poor prognosis
Pancreatic cancer: Elevated in 75%, associated with poor prognosis
Bladder, Bladder Cancer: Click to Expand ⟱
Bladder Cancer
Scientific Papers found: Click to Expand⟱
2952- PL,    Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization
- in-vitro, Bladder, T24/HTB-9 - in-vivo, Bladder, NA
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, ROS↑, Slug↓, β-catenin/ZEB1↓, Zeb1↓, N-cadherin↓, F-actin↓, GSH↓, EMT↓, CLDN1↓, ZO-1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   ROS↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

CLDN1↓, 1,   F-actin↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Zeb1↓, 1,   ZO-1↓, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CLDN1, claudin-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:32  Cells:%  prod#:%  Target#:968  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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