CycB/CCNB1 Cancer Research Results
CycB/CCNB1, Cyclin B: Click to Expand ⟱
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When cyclin B levels are elevated, cells can enter M phase prematurely and strict control over cell division is lost, which is favorable for cancer development.
Cyclin B is a regulatory protein that plays a crucial role in cell cycle progression, particularly in the transition from the G2 phase to mitosis. Its expression levels can significantly impact cancer progression and patient prognosis.
Cyclin B expression is often elevated in various cancers and is generally associated with poor prognosis.
Cyclin B levels:
-Accumulate during S and G2
-Peak at mitotic entry
-Are rapidly destroyed at metaphase–anaphase transition via the APC/C ubiquitin ligase
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Bladder, Bladder Cancer: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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in-vitro, |
Bladder, |
5637 |
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tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ROS↑, 1,
Cell Death ⓘ
Apoptosis↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1,
Transcription & Epigenetics ⓘ
tumCV↓, 1,
DNA Damage & Repair ⓘ
cl‑PARP↑, 1,
Cell Cycle & Senescence ⓘ
p‑CDK1↑, 1, CycB/CCNB1↑, 1,
Drug Metabolism & Resistance ⓘ
eff↓, 1,
Total Targets: 10
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: CycB/CCNB1, Cyclin B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:32 Cells:% prod#:% Target#:379 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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