FOXO3 Cancer Research Results

FOXO3, Forkhead Box O3: Click to Expand ⟱
Source:
Type:
FOXO3 (Forkhead Box O3) is a transcription factor that plays a critical role in regulating apoptosis, cell cycle arrest, DNA repair, and cellular stress responses.

• Positive Prognostic Marker
– In several cancers, higher nuclear FOXO3 expression (denoting active, transcriptionally functional FOXO3) is generally associated with a more favorable prognosis.
– Active FOXO3 can promote cell cycle arrest and apoptosis, thereby inhibiting tumor progression.

• Negative Prognostic Implications
– Conversely, reduced or cytoplasmically sequestered FOXO3 (often due to hyperactivation of the PI3K/Akt signaling pathway) has been linked to aggressive disease and poorer survival
 – Loss of FOXO3 function can allow tumor cells to proliferate unchecked and resist apoptosis, which contributes to a worse outcome.
Bladder, Bladder Cancer: Click to Expand ⟱
Bladder Cancer
Scientific Papers found: Click to Expand⟱
5202- CAP,    Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways
- vitro+vivo, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
antiOx↑, Inflam↓, AntiCan↓, TRPV1↑, TumCP↓, TumCCA↑, ROS↑, FOXO3↑, TumCMig↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↑, 1,  

Cell Death ⓘ

TRPV1↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO3↑, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FOXO3, Forkhead Box O3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:32  Cells:%  prod#:%  Target#:997  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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