β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱

Source: HalifaxProj (inactivate)

Type:

β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.

Arthritis, Arthritis: Click to Expand ⟱

Arthritis

Scientific Papers found: Click to Expand⟱

2506-

H2,

Molecular hydrogen suppresses activated Wnt/β-catenin signaling

in-vivo,

Arthritis,

Rats

*Wnt↓, *β-catenin/ZEB1↓, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Proliferation, Differentiation & Cell State ⓘ

Wnt↓, 1,

Migration ⓘ

β-catenin/ZEB1↓, 1,

Drug Metabolism & Resistance ⓘ

Dose↝, 1,
Total Targets: 3

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells