Raf Cancer Research Results

Raf, RAF kinases: Click to Expand ⟱

Source:

Type:

RAF kinases (ARAF, BRAF and CRAF (also known as RAF1) constitute core components of the RAS-RAF-MEK-ERK signalling cascade (ERK signalling), a pathway that mediates signals from cell surface receptors to the nucleus to regulate cell growth, differentiation and survival.
The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated protein kinase pathway. Hyperactivation of RAF proteins, particularly BRAF and CRAF, drives tumour progression and drug resistance in many types of cancer.

Arthritis, Arthritis: Click to Expand ⟱

Arthritis

Scientific Papers found: Click to Expand⟱

2908-

LT,

Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity

in-vitro,

Arthritis,

*ROS↓, *p‑ERK↓, *p‑MEK↓, *Raf↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

ROS↓, 1,

Mitochondria & Bioenergetics ⓘ

p‑MEK↓, 1, Raf↓, 1,

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,
Total Targets: 4

Scientific Paper Hit Count for: Raf, RAF kinases

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells