CYP3A4 Cancer Research Results
CYP3A4, CYP3A4: Click to Expand ⟱
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CYP3A4 is the most abundant cytochrome P450 enzyme in the liver and is also expressed in extrahepatic tissues.
– It metabolizes a wide range of drugs and endogenous substrates, including hormones.
– In some studies, higher CYP3A4 expression has been correlated with poorer response to treatment and potentially worse survival.
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Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱
Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."
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Scientific Papers found: Click to Expand⟱
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Review, |
Nor, |
NA |
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Review, |
AD, |
NA |
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Review, |
Stroke, |
NA |
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*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Total Targets: 0
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
ROS↓, 1,
Core Metabolism/Glycolysis ⓘ
CYP3A4↓, 1,
Barriers & Transport ⓘ
BBB↑, 1, P-gp↓, 1,
Immune & Inflammatory Signaling ⓘ
Inflam↓, 1,
Drug Metabolism & Resistance ⓘ
BioEnh↑, 1, eff↑, 2, Half-Life↝, 1,
Functional Outcomes ⓘ
neuroP↑, 2, toxicity↝, 1,
Infection & Microbiome ⓘ
Bacteria↓, 1,
Total Targets: 11
Scientific Paper Hit Count for: CYP3A4, CYP3A4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:36 Cells:% prod#:% Target#:1131 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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