Keap1 Cancer Research Results
Keap1, Kelch-like ECH-associated protein 1: Click to Expand ⟱
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Kelch-like ECH-associated protein 1 (Keap1) is a key regulator of the transcription factor Nrf2.
-In several tumor types, loss of Keap1 function (either due to gene mutations or low protein expression) results in unrestrained Nrf2 activity.
• Persistent Nrf2 activation is thought to:
- Provide tumor cells with enhanced protection against oxidative stress.
- Contribute to chemoresistance and radioresistance.
- Promote metabolic reprogramming that fuels tumor growth.
• Thus, in many cancers, altered Keap1 status can serve as an indicator of poor prognosis and has been investigated as a potential target for therapeutic intervention.
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Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱
Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."
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Scientific Papers found: Click to Expand⟱
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Stroke, |
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*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
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*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
GSH↓, 1, ROS↑, 1,
Cell Death ⓘ
Bcl-2↓, 1, Casp12↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1, Cyt‑c↑, 1, Fas↑, 1, p38↑, 1,
DNA Damage & Repair ⓘ
CHK1↓, 1, P53↑, 1,
Cell Cycle & Senescence ⓘ
CycB/CCNB1↓, 1, P21↑, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
STAT3↓, 1,
Migration ⓘ
p‑FAK↓, 1, TumCMig↓, 1,
Angiogenesis & Vasculature ⓘ
Hif1a↓, 1, VEGF↓, 1, VEGFR2↓, 1,
Immune & Inflammatory Signaling ⓘ
IL8↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 1, chemoP↑, 1,
Total Targets: 24
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 3, Catalase↑, 1, GPx↑, 1, GSH↑, 2, GSTs↑, 1, HO-1↑, 1, HO-1⇅, 1, Keap1↓, 2, lipid-P↓, 1, MDA↓, 2, MPO↓, 1, NRF2↑, 3, ROS↓, 4, SOD↑, 2, TBARS↓, 1,
Core Metabolism/Glycolysis ⓘ
ALAT↓, 1, H2S↑, 1, LDH↓, 2, SIRT1↑, 1,
Cell Death ⓘ
Akt↓, 1, Apoptosis↓, 1, iNOS↓, 2,
Transcription & Epigenetics ⓘ
other↑, 1,
Proliferation, Differentiation & Cell State ⓘ
PI3K↓, 1,
Angiogenesis & Vasculature ⓘ
NO↓, 1,
Barriers & Transport ⓘ
BBB↑, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 2, IL6↓, 1, Inflam↓, 2, NF-kB↓, 1, PGE2↓, 1, TNF-α↓, 1,
Protein Aggregation ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1, Half-Life↝, 1,
Clinical Biomarkers ⓘ
ALAT↓, 1, AST↓, 1, BP↓, 1, creat↓, 1, GutMicro↑, 1, IL6↓, 1, LDH↓, 2,
Functional Outcomes ⓘ
AntiCan↑, 1, cardioP↑, 2, cognitive↑, 1, hepatoP↑, 2, memory↑, 2, neuroP↑, 3, RenoP↑, 1,
Total Targets: 49
Scientific Paper Hit Count for: Keap1, Kelch-like ECH-associated protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:36 Cells:% prod#:% Target#:1174 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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