4-HNE Cancer Research Results

4-HNE, 4‑Hydroxynonenal: Click to Expand ⟱
Source:
Type:
4‑Hydroxynonenal (4‑HNE) is a key bioactive aldehyde generated during lipid peroxidation, and it can form adducts with proteins, DNA, and other biomolecules.

4‑HNE can act as a “double‐edged sword”. At moderate concentrations, it might activate signaling pathways that promote cell proliferation and survival, potentially contributing to tumor growth. At higher concentrations, the same molecule may induce cytotoxicity and apoptosis.

-A biomarker of ferroptosis(high levels)
-Elevated levels of 4‑HNE adducts are sometimes associated with chemoresistance and poor clinical outcomes, highlighting its potential role in prognostication.
Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱
Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."
Scientific Papers found: Click to Expand⟱
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   Catalase↑, 1,   GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   cl‑Casp3↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TRPM7↓, 1,   TRPM7⇅, 1,  

Barriers & Transport ⓘ

BBB↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: 4-HNE, 4‑Hydroxynonenal
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:36  Cells:%  prod#:%  Target#:1262  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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