BACE Cancer Research Results
BACE, β-site APP-cleaving enzyme: Click to Expand ⟱
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BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.
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Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱
Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."
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Scientific Papers found: Click to Expand⟱
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Review, |
AD, |
NA |
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Review, |
Park, |
NA |
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Review, |
MS, |
NA |
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Review, |
Stroke, |
NA |
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*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
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in-vitro, |
AD, |
HEK293 |
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NA, |
Stroke, |
NA |
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in-vivo, |
AD, |
NA |
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*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
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Review, |
Var, |
NA |
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Review, |
Stroke, |
NA |
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*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ROS↑, 1,
Cell Death ⓘ
Apoptosis↑, 1,
DNA Damage & Repair ⓘ
DNAdam↑, 1,
Cell Cycle & Senescence ⓘ
TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
EMT↓, 1,
Migration ⓘ
TumCMig↓, 1, TumCP↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, NF-kB↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1,
Total Targets: 12
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 3, GSH↑, 1, GSTs↑, 1, HO-1↑, 1, lipid-P↓, 1, MPO↓, 1, NRF2↑, 1, ROS↓, 3, SOD↑, 1, TAC↑, 1,
Mitochondria & Bioenergetics ⓘ
ATP↑, 1,
Core Metabolism/Glycolysis ⓘ
Acetyl-CoA↓, 1, AMPK↑, 1, CREB↑, 1, FAO↑, 1, PPARγ↑, 1, SIRT1↑, 1,
Cell Death ⓘ
Bax:Bcl2↓, 1, Casp3↓, 1, Casp9↑, 1, iNOS↓, 1,
Protein Folding & ER Stress ⓘ
GRP78/BiP↑, 1, UPR↑, 1,
Proliferation, Differentiation & Cell State ⓘ
GSK‐3β↓, 1,
Migration ⓘ
AntiAg↑, 1,
Barriers & Transport ⓘ
BBB↑, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, IFN-γ↓, 1, IL1β↓, 2, IL33↓, 1, IL6↓, 2, IL8↓, 1, Inflam↓, 3, MyD88↓, 1, NF-kB↓, 2, TLR2↓, 1, TLR4↓, 1, TNF-α↓, 2,
Synaptic & Neurotransmission ⓘ
ADAM10↑, 1, BDNF↑, 1, tau↓, 1, p‑tau↓, 2, TrkB↑, 1,
Protein Aggregation ⓘ
Aβ↓, 3, BACE↓, 3, PP2A↑, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1, BioAv↑, 1, BioAv↝, 1, eff↑, 2,
Clinical Biomarkers ⓘ
BloodF↑, 1, IL6↓, 2,
Functional Outcomes ⓘ
cardioP↑, 1, cognitive↑, 1, memory↑, 2, neuroP↑, 2, RenoP↑, 1,
Infection & Microbiome ⓘ
IRF3↓, 1,
Total Targets: 58
Scientific Paper Hit Count for: BACE, β-site APP-cleaving enzyme
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:36 Cells:% prod#:% Target#:1349 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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