lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
Source:
Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.


Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱
Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."


Scientific Papers found: Click to Expand⟱
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
2625- Ba,  LT,    Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocyte
- in-vivo, Stroke, NA
*lipid-P↓, *ACSL4∅, *NRF2∅, *GPx4∅, *Ferroptosis↓, *ROS↓, *MDA↓, *eff↑, *HO-1∅,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
3627- Cro,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, *monoA↑, *Aβ↓, *AChE↓, *cognitive↑, *neuroP↑, *lipid-P↓, *SOD↑, *ROS↓, *GPx↑, *MDA↓, *memory↑, *antiOx↑, *Inflam↓, *other↓, *ER Stress↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,

Showing Research Papers: 1 to 21 of 21

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

Catalase↑, 1,   CYP1A1↓, 1,   GSH↓, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis

cMyc↓, 1,   Glycolysis↓, 1,  

Cell Death

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp12↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   p38↑, 1,  

Transcription & Epigenetics

other↓, 1,   other↑, 1,  

Autophagy & Lysosomes

BNIP3↑, 1,  

DNA Damage & Repair

CHK1↓, 1,   DNAdam↑, 1,   P53↑, 2,  

Cell Cycle & Senescence

CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State

EMT↓, 1,   IGF-1R↓, 1,   STAT3↓, 1,  

Migration

p‑FAK↓, 1,   TumCMig↓, 2,   TumCP↓, 2,  

Angiogenesis & Vasculature

angioG↓, 2,   Hif1a↓, 2,   VEGF↓, 2,   VEGFR2↓, 2,  

Immune & Inflammatory Signaling

COX2↓, 1,   IL1β↓, 1,   IL8↓, 1,   NF-kB↓, 4,   PGE2↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors

AR↓, 1,  

Drug Metabolism & Resistance

BioAv↝, 1,   eff↑, 3,  

Clinical Biomarkers

AR↓, 1,  

Functional Outcomes

AntiCan↓, 1,   AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

antiOx↑, 15,   Catalase↑, 10,   Ferroptosis↓, 4,   GPx↑, 3,   GPx4↑, 1,   GPx4∅, 1,   GSH↑, 13,   GSTs↑, 3,   H2O2↓, 2,   HNE↓, 1,   HO-1↑, 7,   HO-1∅, 1,   Keap1↓, 1,   lipid-P↓, 20,   mt-lipid-P↓, 1,   MDA↓, 13,   Mets↝, 1,   MPO↓, 3,   NOX4↓, 2,   NQO1↑, 1,   NRF2↑, 11,   NRF2∅, 1,   PARK2↑, 1,   Prx↑, 1,   ROS↓, 23,   SOD↑, 15,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 2,   Trx↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology

IronCh↑, 1,  

Mitochondria & Bioenergetics

ATP↑, 2,   MMP↑, 3,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis

12LOX↓, 1,   ACSL4∅, 1,   ALAT↓, 3,   AMP↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   CRM↑, 1,   H2S↑, 1,   LDH↓, 2,   LDL↓, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death

Akt↓, 2,   Akt↑, 3,   Apoptosis↓, 4,   BAX↓, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   cl‑Casp3↓, 1,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 4,   iNOS↓, 9,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   MAPK↝, 1,   necrosis↓, 1,   p38↑, 1,   p‑p38↓, 1,  

Transcription & Epigenetics

other↓, 2,   other↑, 3,   other↝, 1,  

Protein Folding & ER Stress

ER Stress↓, 1,   HSP70/HSPA5↝, 1,  

Autophagy & Lysosomes

MitoP↑, 1,   p62↓, 1,   p62↑, 1,  

DNA Damage & Repair

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State

ERK↓, 1,   p‑ERK↓, 1,   FOXO↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PI3K↑, 3,   STAT3↓, 1,   TRPM7↓, 1,  

Migration

5LO↓, 2,   AntiAg↑, 3,   Ca+2↓, 2,   Cartilage↑, 2,   E-sel↓, 1,   MMP9↓, 1,   MMPs↓, 1,   PKCδ↑, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature

NO↓, 4,   NO↑, 1,  

Barriers & Transport

BBB?, 1,   BBB↓, 1,   BBB↑, 4,  

Immune & Inflammatory Signaling

COX2↓, 9,   CRP↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IKKα↓, 1,   IL1↓, 1,   IL17↓, 1,   IL1β↓, 10,   IL4↓, 2,   IL6↓, 5,   IL6↑, 1,   IL8↓, 3,   Imm↑, 1,   Inflam↓, 15,   Inflam↑, 1,   MCP1↓, 1,   MyD88↓, 1,   NF-kB↓, 12,   p65↓, 1,   PGE2↓, 2,   TLR2↓, 2,   TLR4↓, 5,   TNF-α↓, 13,  

Synaptic & Neurotransmission

AChE↓, 6,   BChE↓, 2,   BDNF↑, 2,   GABA↑, 1,   GABA↝, 1,   monoA↑, 1,   tau↓, 2,   p‑tau↓, 2,  

Protein Aggregation

Aβ↓, 6,   BACE↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors

GR↑, 1,  

Drug Metabolism & Resistance

BioAv↓, 2,   BioAv↑, 3,   BioAv⇅, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 10,   eff↝, 1,   Half-Life↝, 2,  

Clinical Biomarkers

ALAT↓, 3,   AST↓, 3,   BP↓, 4,   creat↓, 2,   CRP↓, 2,   GutMicro↑, 3,   IL6↓, 5,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 7,   chemoPv↑, 1,   cognitive↑, 8,   hepatoP↑, 4,   memory↑, 8,   motorD↑, 2,   neuroP↑, 19,   Obesity↓, 1,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 2,   Strength↑, 2,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome

IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 174

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
2 Baicalein
2 Quercetin
1 Allicin (mainly Garlic)
1 Luteolin
1 Berberine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Carnosine
1 Chocolate
1 Chrysin
1 Crocetin
1 Fisetin
1 Lycopene
1 Pterostilbene
1 Resveratrol
1 Rutin
1 Silymarin (Milk Thistle) silibinin
1 Taurine
1 Thymoquinone
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:36  Cells:%  prod#:%  Target#:453  State#:%  Dir#:1
wNotes=0 sortOrder:rid,rpid

 

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