ARE Cancer Research Results

ARE, antioxidant responsive element (ARE): Click to Expand ⟱

Source:

Type:

antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance

Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱

Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."

Scientific Papers found: Click to Expand⟱

5864-

CA,

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

vitro+vivo,

Stroke,

PC12

Male C57BL/6 mice, aged 6–8 week

*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

ARE↑, 1, GSH↑, 1, HO-1↑, 1, NQO1↑, 1, NRF2↑, 1, ROS↓, 1,

Barriers & Transport ⓘ

BBB↑, 1,

Functional Outcomes ⓘ

neuroP↑, 1,
Total Targets: 8

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells