memory Cancer Research Results

memory, memory: Click to Expand ⟱

Source:

Type:

Memory

AD, Alzheimer's Disease: Click to Expand ⟱

Brain Energy Systems Matrix (AD)

Tier 1–2 as “core metabolic cofactors / redox pools”
Tier 4 as “alternative fuels / bypass strategies”
Tier 5–6 as “capacity + delivery constraints” (often explains why supplements don’t translate)

Tier	Rank	Node / Lever	What it Supports (Bioenergetic Role)	Key Enzymes / Targets	AD-Relevant Mechanism	TSF	Evidence	Common Constraints / Gotchas
1	1	Thiamine (B1) / TPP	Glucose → acetyl-CoA entry + TCA throughput + NADPH support	PDH, α-KGDH, Transketolase (PPP)	Addresses cerebral glucose hypometabolism; improves mitochondrial flux; PPP→NADPH supports redox	R, G	Mechanistic + small clinical	Benefit strongest if low status; standard thiamine vs lipophilic derivatives differ
1	2	Benfotiamine	Higher-bioavailability B1 strategy	Transketolase ↑; glycation axis ↓	AGE/RAGE burden reduction + metabolic support (model/trial dependent)	G	Small clinical + mechanistic	Not a “rapid” effect; mostly longer-term metabolic/toxicity load reduction
1	3	Riboflavin (B2) / FAD, FMN	ETC redox enzymes + mitochondrial dehydrogenases	Complex I/II flavoproteins; many oxidoreductases	Supports electron handling; can be limiting in mitochondrial enzyme insufficiency	R, G	Mechanistic	Direct AD cognitive trial support limited; “helps” mostly when deficient or enzyme-limited
1	4	Niacin forms (B3) → NAD pool	NAD+/NADH redox + signaling + repair	NAD salvage; sirtuins; PARP substrate	NAD decline is an aging/inflammation theme; supports mitochondrial redox capacity	R, G	Emerging human + mechanistic	Different forms behave differently; NAD raising ≠ guaranteed clinical cognition benefit
1	5	Pantothenic acid (B5) → CoA	Acetyl-CoA formation; lipid metabolism; TCA entry	CoA biosynthesis; acetylation capacity	Foundational for fuel oxidation and acetylation balance	G	Mechanistic	Often overlooked; deficiency uncommon but suboptimal intake can matter in frailty
1	6	Magnesium	ATP handling (Mg-ATP) + enzyme kinetics	ATP-dependent enzymes; synaptic function	Supports neuronal energy usage + plasticity; deficiency can worsen excitotoxic vulnerability	R, G	Supportive human + mechanistic	Form/absorption variability; renal constraints for supplementation in some patients
2	1	NAD+ precursors (NR/NMN/NA/NAM)	Restores NAD+ availability for redox + signaling	NAMPT salvage; sirtuins; PARPs; CD38	Supports mitochondrial function; may improve resilience under oxidative/repair load	R, G	Animal > human (emerging)	NAD “sinks” (CD38/PARP) can dominate; response varies by inflammation/age
2	2	Alpha-lipoic acid (ALA)	Mitochondrial redox cofactor + antioxidant recycling	PDH/α-KGDH cofactor; GSH recycling support	Improves redox tone and mitochondrial efficiency (signals strongest in metabolic/oxidative phenotypes)	R, G	Small AD trials + mechanistic	“Antioxidant” framing can be misleading—main value is mitochondrial/redox coupling support
2	3	Glutathione system support	Detox + peroxide handling	GSH, GPx, GR, NADPH supply (PPP)	Reduces oxidative damage load that impairs mitochondria/synapses	R, G	Mechanistic	GSH depends on substrates + NADPH; pushing one component may not fix system
2	4	Selenium (GPx capacity)	Peroxide detox via selenoenzymes	Glutathione peroxidases	Supports antioxidant enzyme capacity (context-dependent)	G	Mixed human	Narrower safety margin; avoid “more is better” mindset
3	1	CoQ10 (ubiquinone)	ETC electron carrier (I/II→III) + membrane redox	Complex I/II→III transfer	Supports OXPHOS efficiency; may reduce electron leak under some conditions	R, G	Limited AD-specific	Bioavailability/formulation matters; AD cognition data not robust
3	2	Cardiolipin / mitochondrial membranes (support axis)	ETC supercomplex stability; cristae integrity	Inner mitochondrial membrane architecture	Membrane integrity affects ETC efficiency and ROS leak	G	Mechanistic	Hard to “target” nutritionally in a clean way; effects indirect
3	3	Iron / copper homeostasis (burden control)	Prevents metal-catalyzed oxidative damage	Fenton chemistry burden; metal transport/storage	Metal dyshomeostasis can amplify ROS and mitochondrial injury	R, G	Mechanistic + mixed human	“Chelation” is not casually safe; needs careful framing and evidence
4	1	Ketone utilization (BHB/acetoacetate axis)	Alternative brain fuel bypassing glucose bottlenecks	MCT1/2 transport; ketolysis enzymes	Addresses brain glucose hypometabolism by providing alternate substrate	R, G	Moderate (human MCI/AD signals exist)	GI tolerance and adherence; response varies by genotype/metabolic status
4	2	Creatine / phosphocreatine shuttle	ATP buffering and rapid energy stabilization	Creatine kinase system	May stabilize energy during stress; supports muscle/functional reserve that impacts cognition indirectly	G	Limited AD	CNS benefit uncertain; stronger for muscle/functional outcomes
4	3	Acetyl-L-carnitine (ALCAR)	Fatty acid oxidation support + acetyl group handling	Carnitine shuttle; acetyl-CoA support	May support mitochondrial energy and neuronal function (mixed clinical results)	R, G	Mixed human	Benefits heterogeneous; not a universal cognitive improver
4	4	Medium-chain triglycerides (MCT oil → ketones)	Rapid ketone support strategy	Hepatic ketogenesis; brain ketone uptake	Practical ketone-raising approach for some phenotypes	R, G	Moderate human	GI effects; calorie load; titration matters
5	1	AMPK → PGC-1α biogenesis axis	Mitochondrial number/quality regulation	AMPK, PGC-1α, SIRT1	Supports long-term mitochondrial capacity and stress resistance	G	Mechanistic	Most effects are slow; many “activators” are indirect and context-dependent
5	2	Mitophagy / autophagy quality control	Removes damaged mitochondria	PINK1/Parkin axis; autophagy machinery	Damaged mitochondria drive ROS and energy failure; quality control is protective in theory	G	Mechanistic	Autophagy modulation is double-edged; oversimplified “more autophagy = good” is risky
5	3	Exercise signaling (the “master cofactor”)	Improves vascular + mitochondrial + neurotrophic tone	BDNF; insulin sensitivity; AMPK/PGC-1α	Most evidence-backed multi-pathway energy intervention for aging brain	R, G	Strong (human)	Adherence/ability constraints; must be individualized
6	1	Cerebral perfusion / vascular health	Fuel + oxygen delivery and waste clearance support	Neurovascular unit; endothelial function	Vascular dysfunction worsens hypometabolism and inflammation	R, G	Strong (human)	Often upstream of “supplement” efficacy; if delivery is poor, cofactors underperform
6	2	Sleep / glymphatic clearance	Waste clearance & metabolic recovery	Glymphatic system; circadian regulation	Supports clearance of metabolic byproducts; indirectly supports energy balance	G	Strong (human)	Often neglected; impacts cognition and inflammation strongly
6	3	Oxygen utilization context (respiratory capacity)	Oxidative metabolism support	OXPHOS dependence	If oxygen delivery/usage is limited, pushing mitochondrial cofactors won’t fully translate	R, G	Supportive	More about system constraints than a “node to supplement”

TSF (Time-Scale Flag): P = 0–30 min, R = 30 min–3 hr, G = >3 hr (adaptation/phenotype). Evidence: "Strong (human)" = consistent clinical/epidemiologic support; "Moderate" = mixed but plausible human signals; "Emerging" = early-stage human; "Mechanistic" = preclinical/biochemical rationale.

Scientific Papers found: Click to Expand⟱

4039-

Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI

Study,

AD,

*cognitive↑, *memory↑, *Mood↑,

5297-

5-HTP,

Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases

in-vivo,

AD,

in-vivo,

Park,

*other↝, *cognitive↑, *memory↑, *Ach↑,

5293-

5-HTP,

The Role of Tryptophan Metabolism in Alzheimer’s Disease

in-vivo,

AD,

*Sleep↑, *5HT↑, *memory↑, *other↝,

5289-

5-HTP,

5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology

Review,

AD,

Review,

Arthritis,

*5HT↑, *Inflam↓, *memory↑, *Sleep↑, *Weight↓, *DNAdam↓, *ROS↓, *toxicity↝,

3969-

ACNs,

Blueberry Supplementation in Midlife for Dementia Risk Reduction

Human,

AD,

Freeze-Dried Blueberry, 0.5 c whole-fruit equivalent administered once each day

Thirty-three participants

*memory↑, *cognitive↑, *ROS↓,

3971-

ACNs,

Blueberry Supplementation Improves Memory in Older Adults

Human,

AD,

wild blueberry juice in a sample of nine older adults with early <span class="wphighlight">memory</span> changes

*antiOx↑, *Inflam↓, *memory↑, *neuroP↑, *cognitive↑, *Mood↑, *glucose↓,

3972-

ACNs,

Recent Research on the Health Benefits of Blueberries and Their Anthocyanins

Review,

AD,

Review,

Park,

*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,

3865-

ACNs,

Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia

Human,

AD,

200 ml/day cherry juice

*memory↑, *BP↓, *cognitive↑,

4163-

ACNs,

Flav,

Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor

in-vivo,

AD,

Rats

memory↑, *BDNF↑, *cognitive↑,

2657-

AL,

Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases

Review,

CardioV,

Review,

AD,

*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,

2660-

AL,

Allicin: A review of its important pharmacological activities

Review,

AD,

Review,

Var,

Review,

Park,

Review,

Stroke,

*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,

3269-

ALA,

Sulfur-containing therapeutics in the treatment of Alzheimer’s disease

NA,

AD,

*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,

3271-

ALA,

Decrypting the potential role of α-lipoic acid in Alzheimer's disease

Review,

AD,

*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,

3438-

ALA,

The Potent Antioxidant Alpha Lipoic Acid

Review,

NA,

Review,

AD,

*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,

3443-

ALA,

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention

Review,

Var,

Review,

AD,

*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27↑, PDH↑, Glycolysis↓, ROS↑, *eff↑, *memory↑, *motorD↑, *GutMicro↑,

3549-

ALA,

Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia

Review,

AD,

*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,

3547-

ALA,

Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration

Review,

AD,

Review,

Park,

*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,

3546-

ALA,

Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study

Study,

AD,

fifteen elder patients (mean age: 84.5 ± 5.77) received ALA at a daily dose of 600 mg/day for 12 weeks.

*antiOx↑, *ROS↓, *cognitive∅, *lipid-P↓, *memory↑, *ChAT↑, *Acetyl-CoA↑, *Aβ↓, *BioAv↑, *BBB↑, *toxicity∅,

3545-

ALA,

Potential therapeutic effects of alpha lipoic acid in memory disorders

Review,

AD,

*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,

3544-

ALA,

Alpha lipoic acid for dementia

Review,

AD,

*antiOx↑, *BBB↑, *VitC↑, *VitE↑, *GSH↑, *IronCh↑, *neuroP↑, *NO↓, *cognitive↑, *AntiAge↑, *memory↑, *ROS↓,

297-

ALA,

Insights on the Use of α-Lipoic Acid for Therapeutic Purposes

Review,

BC,

SkBr3

Review,

neuroblastoma,

SK-N-SH

Review,

AD,

PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,

3887-

Api,

The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice

in-vivo,

AD,

mice

*Inflam↓, *ROS↓, *Aβ↓, *memory↑, *AChE↓, *Ach↑, *Dose↑, *BDNF↑, *TrkB↑, *p‑CREB↑, *BBB↑, *Ca+2?,

3885-

Api,

Anti-Inflammatory and Neuroprotective Effect of Apigenin: Studies in the GFAP-IL6 Mouse Model of Chronic Neuroinflammation

in-vivo,

AD,

GFAP-IL6 mice.

*memory↑, *Inflam↓, *neuroP↑,

3884-

Api,

Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model

in-vivo,

AD,

double transgenic AD mice

*memory↑, *Aβ↓, *BACE↓, *antiOx↑, *BDNF↑, *p‑CREB↑, *p‑ERK↑, *ROS↓, *SOD↑, *GPx↑, *neuroP↑,

3821-

Aroma,

Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants

Review,

AD,

*cognitive↑, *AChE↓, *BChE↓, *ROS↓, *other↓, *other↓, *other↓, *other↓, *other↓, *memory↑, *BACE↓, *Mood↑, *motorD↑,

3824-

Aroma,

Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties

Human,

AD,

 20 healthy, young participants

*cognitive↑, *memory↑, *AChE∅, *Mood↑, *eff↝,

3825-

Aroma,

The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis

Review,

AD,

*memory↑, *Mood↑,

3826-

Aroma,

A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia

Human,

AD,

 Forty-nine nursing home residents with dementia (n=39) and without dementia (n=10) exhibiting agitation

*Mood↑, *memory↑,

3665-

ART/DHA,

Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation

Review,

AD,

*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,

3666-

ART/DHA,

Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling

NA,

AD,

*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2↓, *cognitive↑,

3687-

Ash,

Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives

Review,

AD,

*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,

5425-

ASTX,

Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights

in-vivo,

AD,

*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,

3833-

BBR,

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

Review,

AD,

*cardioP↑, *neuroP↑, *memory↑, *Aβ↓,

3677-

BBR,

Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease

Review,

AD,

0.44uM(AChEi)

*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,

3679-

BBR,

Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway

in-vivo,

AD,

5xFAD mice

*Beclin-1↑, *LC3B↑, *p62↓, *ROS↓, *lipid-P↓, *MDA↓, *Ferroptosis↓, *TfR1/CD71↓, *FTH1↑, *memory↑, *JNK↓, *p38↓, *Aβ↓, *Inflam↓,

3680-

BBR,

Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway

in-vivo,

AD,

3 × Tg AD mice

*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,

3681-

BBR,

The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology

in-vivo,

AD,

mouse

*memory↑, *cognitive↑, MAPK↑, *Akt↑, *PI3K↑, *TP53↑, *Jun↓, *HSP90↑, *neuroP↑, *Inflam↓, *antiOx↑, *p16↓, *ER Stress↓,

3684-

BBR,

Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies

Review,

AD,

*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,

4298-

BBR,

Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance

in-vivo,

AD,

in drinking water at 100 mg/kg/day, and lasted four months

3×Tg AD mice

*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1↑,

4299-

BBR,

Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation

in-vivo,

AD,

AD mice

*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,

5633-

BCA,

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Review,

Var,

Review,

AD,

*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,

5565-

betaCar,

β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure

Study,

AD,

*Risk↓, *memory↑, *Aβ↓,

4061-

betaCar,

VitB12,

VitB6,

FA,

VitB3

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Review,

AD,

*cognitive↑, *cognitive↑, *Inflam↓, *homoC↓, *TNF-α↓, *other↝, *memory↑,

4082-

betaCar,

Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis

Study,

AD,

*cognitive↑, *BACE↓, *memory↑,

5485-

BM,

Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis

Review,

AD,

*memory↑,

5473-

BM,

Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability

in-vivo,

AD,

in-vivo,

Park,

*neuroP↑, *toxicity∅, *AChE↓, *ROS↓, *antiOx↑, *lipid-P↓, *cognitive↑, *memory↑, *Dose↝, *BioAv↓, *TumCCA↑, *BBB↝,

3697-

BM,

Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies

Review,

AD,

*ROS↓, *cognitive↑, *memory↑, *BBB↑, *P-gp↓, *CYP3A2↓,

3690-

BM,

Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease

Review,

AD,

*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,

5663-

BNL,

Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice

in-vivo,

AD,

mice

*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE↓, *cognitive↑, *BioAv↑, memory↑, P-gp↓, BioEnh↑,

760-

Bor,

Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease

in-vivo,

AD,

rats

*memory↑, *ROS↓, *GSH↑, *Aβ↓, *Inflam↓, *MMP↑, *lipid-P↓, *Ca+2↓, *cognitive↑, *TOS↓,

Showing Research Papers: 1 to 50 of 247
Page 1 of 5 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 247

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↓, 2, antiOx↑, 18, Catalase↑, 4, Ferroptosis↓, 1, GPx↑, 6, GSH↑, 13, GSR↑, 1, GSTs↑, 2, HDL↑, 1, HO-1↑, 5, Keap1↓, 1, lipid-P↓, 15, MDA↓, 5, MPO↓, 2, NQO1↑, 2, NRF2↑, 8, RNS↓, 1, ROS↓, 29, ROS↑, 1, SOD↑, 10, TBARS↓, 2, TOS↓, 1, VitC↑, 4, VitE↑, 3,

Metal & Cofactor Biology ⓘ

FTH1↑, 1, IronCh↑, 8, TfR1/CD71↓, 1,

Mitochondria & Bioenergetics ⓘ

ATP↑, 1, MMP↑, 1, mtDam↑, 1,

Core Metabolism/Glycolysis ⓘ

ACC↑, 1, Acetyl-CoA↑, 2, adiP↓, 1, adiP↑, 1, ALAT↓, 1, cAMP↑, 1, p‑CREB↑, 2, CYP3A2↓, 1, glucose↓, 1, GlucoseCon↑, 5, H2S↑, 1, homoC↓, 1, LDH↓, 2, LDL↓, 2, NADPH↑, 1, PDH↑, 1, PDKs↓, 1,

Cell Death ⓘ

Akt↓, 2, Akt↑, 4, Apoptosis↓, 2, Bax:Bcl2↓, 1, cl‑Casp3↓, 1, Casp6↓, 1, Casp9↓, 1, Ferroptosis↓, 1, iNOS↓, 6, JNK↓, 2, MAPK↓, 1, p38↓, 1,

Transcription & Epigenetics ⓘ

Ach↑, 8, other↓, 6, other↑, 2, other↝, 6,

Protein Folding & ER Stress ⓘ

ER Stress↓, 2, HSP70/HSPA5↑, 1, HSP90↑, 2, HSPs↝, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2, LC3B↑, 1, LC3II↑, 1, p62↓, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 1, p16↓, 1, TP53↑, 1,

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1, p‑ERK↑, 2, GSK‐3β↓, 2, IGF-1↑, 1, Jun↓, 1, mTOR↓, 1, P70S6K↓, 1, PI3K↓, 2, PI3K↑, 1,

Migration ⓘ

5LO↓, 1, APP↓, 2, Ca+2?, 1, Ca+2↓, 2, CD31↑, 1, N-cadherin↑, 1, VCAM-1↓, 2, ZO-1↓, 1,

Angiogenesis & Vasculature ⓘ

p‑eNOS↑, 1, Hif1a↑, 1, NO↓, 5, VEGF↑, 2,

Barriers & Transport ⓘ

BBB↑, 11, BBB↝, 1, GLUT3↑, 2, GLUT4↑, 2, P-gp↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 3, CRP↓, 1, IL1β↓, 6, IL6↓, 4, Inflam↓, 25, Inflam↑, 1, MyD88↓, 1, NF-kB↓, 10, p‑NF-kB↓, 1, PGE2↓, 1, TLR4↓, 2, TNF-α↓, 6,

Synaptic & Neurotransmission ⓘ

5HT↑, 4, AChE↓, 11, AChE∅, 1, BChE↓, 4, BDNF↑, 3, ChAT↑, 9, MAOA↓, 3, tau↓, 1, p‑tau↓, 4, TrkB↑, 1,

Protein Aggregation ⓘ

Aβ↓, 16, BACE↓, 7, MAOB↓, 2, PP2A↑, 1,

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1, RAAS↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 3, BioAv↑, 5, BioAv↝, 4, Dose↑, 1, Dose↝, 2, eff↓, 3, eff↑, 2, eff↝, 2, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 2,

Clinical Biomarkers ⓘ

ALAT↓, 1, ALP↓, 1, AST↓, 2, BP↓, 4, creat↓, 1, CRP↓, 1, GutMicro↑, 3, IL6↓, 4, LDH↓, 2, TP53↑, 1,

Functional Outcomes ⓘ

AntiAge↑, 3, AntiCan↑, 1, AntiDiabetic↑, 1, AntiTum↑, 1, BOLD↑, 1, cardioP↓, 1, cardioP↑, 6, cognitive↑, 32, cognitive∅, 1, hepatoP↑, 3, memory↑, 48, Mood↑, 6, motorD↑, 3, neuroP↑, 27, Obesity↓, 1, Risk↓, 4, Sleep↑, 2, toxicity↓, 3, toxicity↝, 1, toxicity∅, 2, Weight↓, 2,

Infection & Microbiome ⓘ

Bacteria↓, 1,
Total Targets: 172

Scientific Paper Hit Count for: memory, memory

15 Magnetic Fields
11 Urolithin
10 Alpha-Lipoic-Acid
10 Curcumin
9 Thymoquinone
8 Berberine
8 Hydrogen Gas
6 Folic Acid, Vit B9
6 Choline
6 Moringa oleifera
6 Resveratrol
6 Rosmarinic acid
6 Salvia officinalis
5 Anthocyanins
5 Aromatherapy
5 Crocetin
5 Magnetic Field Rotating
5 Phosphatidylserine
4 Vitamin B12
4 Bacopa monnieri
4 Chlorogenic acid
4 EGCG (Epigallocatechin Gallate)
4 Ferulic acid
4 Ginseng
4 Lutein
4 Zeaxanthin
4 Lycopene
4 Rutin
4 Silymarin (Milk Thistle) silibinin
4 Taurine
3 5-Hydroxytryptophan
3 Apigenin (mainly Parsley)
3 beta-carotene(VitA)
3 Vitamin B3,Niacin
3 Ginkgo biloba
3 EMF
3 Piperine
3 Quercetin
3 Shankhpushpi
3 Vitamin B1/Thiamine
2 Allicin (mainly Garlic)
2 Artemisinin
2 Carnosic acid
2 Capsaicin
2 Carvacrol
2 diet Short Term Fasting
2 Exercise
2 Shilajit/Fulvic Acid
2 Honokiol
2 MCToil
2 probiotics
2 Radio Frequency
2 Ursolic acid
2 Vitamin K2
1 flavonoids
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Biochanin A
1 Vitamin B6,pyridoxine
1 borneol
1 Boron
1 Boswellia (frankincense)
1 Caffeic acid
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Celastrol
1 chitosan
1 Lecithin
1 Coenzyme Q10
1 Galantamine
1 Huperzine A/Huperzia serrata
1 Luteolin
1 Vitamin E
1 Methylene blue
1 Metformin
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Parthenolide
1 Pterostilbene
1 Selenium
1 Selenium NanoParticles
1 Sulforaphane (mainly Broccoli)
1 Spermidine
1 Selenite (Sodium)
1 Vitamin A, Retinoic Acid
1 Vitamin B5,Pantothenic Acid
1 Zinc

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:38  Cells:%  prod#:%  Target#:558  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

memory Cancer Research Results

Brain Energy Systems Matrix (AD)

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Home Page