Dose Cancer Research Results

Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
AD, Alzheimer's Disease: Click to Expand ⟱
In Alzheimer's disease (AD), cholinergic dysfunction (often with reduced acetylcholine tone and impaired choline metabolism) is linked with cortical dysfunction, memory deficit, abnormal cerebral blood flow, task learning difficulty, sleep-cycle disruption, and neurodevelopmental effects (context-dependent).
CORE HALLMARKS / HIGH-CONFIDENCE AXES:
- tau and Aβ, their accumulation in AD brains is known to be a major hallmark.
  In AD, PP2A↓ activity is decreased (reported), contributing to hyperphosphorylated tau accumulation.
  SIRT-1↓ levels in AD brains are associated with accumulation of Aβ and tau (reported).
- glucose metabolism↓ (brain glucose hypometabolism) occurs in AD long before significant clinical signs in many cohorts/models (reported).
- Neuroinflammation / lipid mediator tone (reported): 5-LOX↑ and PGE2↑ (model-/region-dependent).
- Synaptic vulnerability (reported): PSD95↓ in hippocampus and cortex; restoring PSD95 shows cognitive benefits in models.
- Clearance/transport imbalance (reported): IDE↓, NEP↓, LRP1↓, and AEP↑ protein levels in AD brains (reported).

COMMONLY REPORTED DIRECTIONAL CHANGES (model/region/compartment dependent):
- Monoamines (reported): concentrations of 5-HTP↓, 5-HT(seratonin)↓, and 5-HIAA↓ are lower in Alzheimer's patients (varies by region/study).
- Cholinergic system (clinical target): reduction in ACh↓ production; ChAT↓ activity reduced (synthesizes ACh).
- Four key enzymes frequently targeted in AD symptom/adjunct strategies: AChE, BChE, MAOA, MAOB (objective inhibit).
- Neurotrophic tone (reported): BDNF↓ in key regions.
  - Stress can decrease expression of brain-derived neurotrophic factor (BDNF).
- Kinase/protease stress (reported): CDK5↑ hyperactivation; calpain↑ overactivated by increased intracellular Ca²⁺ → p-tau and aggregation.
- Aβ-linked synaptic regulator (reported): STEP↑ upregulated largely due to Aβ oligomer accumulation.
- α-secretase axis (reported): ADAM10↓ downregulated in AD brains.
- Metabolic cofactors (reported): ALC↓ (ALCAR); Homocarnosine↓ (CSF declines with age); possible low Taurine↓ (age-related + dementia reports).
- Ion/glutamate handling (reported): impaired glutamate clearance + depressed Na+/K+ ATPase → cellular ion imbalance risk.
- Aging reduces NAD⁺↓ (in AD depletion may be more severe).
- Mitochondrial capacity axis (reported): PGC-1↓ decreased in Alzheimer’s brains.
- Innate immune DNA-sensing axis (animal): cGAS–STING↑ elevation observed in AD mice and normalized by NR treatment.
- Vascular/structure (reported): a profound change in BBB permeability; progressive brain shrinkage (atrophy).
- Glycation axis (reported): AGEs↑ and RAGE↑ expression.

HOMOCYSTEINE / B-VITAMIN AXIS:
- Raised plasma total homocysteine (tHcy)↑ associated with cognitive impairment, AD, or vascular dementia (epidemiology).
  - Homocysteine can build up if vitamin B6, B12, or folate levels are low.
  - Homocysteine and B-vitamin in Cognitive Impairment (VITACOG) study.
  - Vit B6 might be an important B vitamin (often discussed along with B12 and folate).
- Thiamine↓ deficiency produces a cholinergic deficit (well-aligned with AD features).
- Decreased thiamine (B1) in AD may exacerbate Aβ deposition, tau hyperphosphorylation, and oxidative stress (reported).

MICRONUTRIENTS / CAROTENOIDS (reported; compartment-dependent):
- vitamin A↓ and β-carotene↓ lower in some AD cohorts; excess retinol may contribute to osteoporosis risk.
- Diminished circulating vitamin E↓ reported in AD.
- Vitamin B5↓ in multiple brain regions (reported).
- Trace elements: patients with AD reported lower serum Se, Cu, and Zn↓ (serum findings vary by study).
- Brain metals: some studies report higher brain copper↑ and iron↑ in specific regions/structures; compartment and region matter.
  Rosmarinic acid reported to reduce copper-induced neurotoxicity in vitro/in vivo and may interfere with amyloid–copper interactions (preclinical).
- SAMe↓ concentrations in CSF reported in AD.
- MPOD often reduced in AD patients.
- AD brains reported lower levels of lutein↓, zeaxanthin↓, anhydrolutein↓, (VitA)retinol↓, lycopene↓, alpha-tocopherol↓.

RISK CONTEXT:
- Apolipoprotein E4 (ApoE4) genotype is the strongest known genetic risk factor for late-onset AD.
  - One copy of ApoE4: ~3–4× increased risk (range varies by cohort).
  - Two copies: ~8–12× increased risk (range varies).
  - VitK lower in circulating blood of APOE4 carriers (reported).
- Type 2 diabetes, traumatic brain injury, stroke, diet, and above all, aging is the number ONE risk factor.

Treatments / Strategy Targets (high-level):
- Early intervention tends to have a greater positive effect than interventions during middle or late stages.
- BOLD fMRI imaging can be used to observe brain activity via blood oxygen/flow changes.
- Reduce ROS and inflammation in the brain (context-dependent; avoid over-suppressing adaptive signaling).
- Inhibiting acetylcholinesterase (AChE) (which breaks down ACh), e.g., donepezil, rivastigmine.
- Natural AChE inhibitors include: Berberine, Luteolin, Crocetin(saffron), Querctin, TQ
- Natural AChE inhibitors in database (check BBB pass potential).
- MAOB inhibitors, APP inhibitors, PGE2 inhibitors, NLRP3 inhibitors, BACE inhibitors
- BDNF activators, PSD95 activator
- STEP, ADAM10
- Diets with an adequate ratio (5:1) of omega-6:3 (Mediterranean diet).
- Vitamins B1, B6, B12, B9 (folic acid) and D, choline, iron and iodine exert neuroprotective effects (general nutrition framing).
- Antioxidants (vitamins C, E, A, zinc, selenium, lutein and zeaxanthin).
- Fiber may promote gut microbiome diversity influencing brain health.
- Supplementing with NAD⁺ precursors (NR or NMN) improves cognition and reduces amyloid/tau pathologies in AD mice (animal evidence).
- "It is advisable to consume diets with an adequate ratio (5:1) of omega-6:3 fatty acids (Mediterranean diet) ... antioxidants ... role in oxidative stress ... cognition." Nutrition Strategies
- Reduction of cognitive decline may be achieved by following a healthy dietary pattern limiting added sugars while maximizing fish, fruits, vegetables, nuts, seeds.

SeNPs may also be useful as a Drug Delivery System.


Related Pathways to research in this database (products that modulate them):
- neuroprotective, cognitive, memory
- Aβ aggregation, Tau↓, AChE↓, ACh↑, ChAT↑, acetyl-CoA↑, BDNF↑, BACE↓, NLRP3↓, PSD95↑, PGE2↓, homoC↓
- Increasing AntiOxidants: Catalase↑, GSH↑, SOD↑, HO-1↑, to decrease ROS↓
- Lower Inflammation: TNF-α↓, IL1β↓, IL6↓

Natural Products that may benefit AD.
-Some key pathways are highlighted in RED in the following links
Acetyl-L-carnitine, ALA, Apigenin, Anthocyanins Blueberrys, Aromatherapy, Artemisinin, Ashwagandha,
β-carotene(vitamin A), Bacopa monnieri, Baicalein, Baicalin, Berberine, Betulinic acid, Boron, Boswellia (frankincense),
Caffeic acid, Caffeine, Capsaicin, Carnosine, Carnosic acid, Chlorogenic acid, Choline, Chrysin, Cinnamon, CoQ10, Crocetin, Curcumin,
dietMed, dietMet, dietSTF, EGCG, Ellagic acid, Exercise, Ferulic Acid, Fisetin, Flav, FLS, Folic Acid (5-MTHF, L-methylfolate)-reduce homocysteine,
Galantamine, Ginger, Ginkgo biloba, Ginseng,
Honokiol, Huperzine A, hydrogen gas, Lecithin, Lutein, Luteolin, Lycopene,
M-Blu, Moringa oleifera, Mushroom Lion’s Mane, MSM, MCToil, NAD, Naringenin,
PEMF, Piperine, Phenylbutyrate, Phosphatidylserine, Piperlongumine, Potassium, probiotics, Propolis, Pterostilbene,
Quercetin, Resveratrol, Rivastigmine, Rosmaric Acid(reduce copper-induced neurotoxicity), Rutin,
Safflower yellow, Sage, SAMe, selenium, Serotonin, Shankhpushpi, Shikonin, Shilajit/Fulvic Acid, silicon(reduce Alum bioavialability), Silymarin (Milk Thistle) silibinin, Sulforaphane,
Taurine, TQ, Ursolic Acid
Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6, Vitamin B12, Vitamin E, Vitamin D, Vitamin K2
Zeaxanthin, zinc,

Aluminium has a negative impact on cognition but silicon can decrease Alumunium bioavailability, and Vitamin K2 may provide some protection. Example So does RMF

Brain Energy Systems Matrix (AD)

Tier 1–2 as “core metabolic cofactors / redox pools”
Tier 4 as “alternative fuels / bypass strategies”
Tier 5–6 as “capacity + delivery constraints” (often explains why supplements don’t translate)
Tier Rank Node / Lever What it Supports (Bioenergetic Role) Key Enzymes / Targets AD-Relevant Mechanism TSF Evidence Common Constraints / Gotchas
11 Thiamine (B1) / TPP Glucose → acetyl-CoA entry + TCA throughput + NADPH support PDH, α-KGDH, Transketolase (PPP) Addresses cerebral glucose hypometabolism; improves mitochondrial flux; PPP→NADPH supports redox R, G Mechanistic + small clinical Benefit strongest if low status; standard thiamine vs lipophilic derivatives differ
12 Benfotiamine Higher-bioavailability B1 strategy Transketolase ↑; glycation axis ↓ AGE/RAGE burden reduction + metabolic support (model/trial dependent) G Small clinical + mechanistic Not a “rapid” effect; mostly longer-term metabolic/toxicity load reduction
13 Riboflavin (B2) / FAD, FMN ETC redox enzymes + mitochondrial dehydrogenases Complex I/II flavoproteins; many oxidoreductases Supports electron handling; can be limiting in mitochondrial enzyme insufficiency R, G Mechanistic Direct AD cognitive trial support limited; “helps” mostly when deficient or enzyme-limited
14 Niacin forms (B3) → NAD pool NAD+/NADH redox + signaling + repair NAD salvage; sirtuins; PARP substrate NAD decline is an aging/inflammation theme; supports mitochondrial redox capacity R, G Emerging human + mechanistic Different forms behave differently; NAD raising ≠ guaranteed clinical cognition benefit
15 Pantothenic acid (B5) → CoA Acetyl-CoA formation; lipid metabolism; TCA entry CoA biosynthesis; acetylation capacity Foundational for fuel oxidation and acetylation balance G Mechanistic Often overlooked; deficiency uncommon but suboptimal intake can matter in frailty
16 Magnesium ATP handling (Mg-ATP) + enzyme kinetics ATP-dependent enzymes; synaptic function Supports neuronal energy usage + plasticity; deficiency can worsen excitotoxic vulnerability R, G Supportive human + mechanistic Form/absorption variability; renal constraints for supplementation in some patients
21 NAD+ precursors (NR/NMN/NA/NAM) Restores NAD+ availability for redox + signaling NAMPT salvage; sirtuins; PARPs; CD38 Supports mitochondrial function; may improve resilience under oxidative/repair load R, G Animal > human (emerging) NAD “sinks” (CD38/PARP) can dominate; response varies by inflammation/age
22 Alpha-lipoic acid (ALA) Mitochondrial redox cofactor + antioxidant recycling PDH/α-KGDH cofactor; GSH recycling support Improves redox tone and mitochondrial efficiency (signals strongest in metabolic/oxidative phenotypes) R, G Small AD trials + mechanistic “Antioxidant” framing can be misleading—main value is mitochondrial/redox coupling support
23 Glutathione system support Detox + peroxide handling GSH, GPx, GR, NADPH supply (PPP) Reduces oxidative damage load that impairs mitochondria/synapses R, G Mechanistic GSH depends on substrates + NADPH; pushing one component may not fix system
24 Selenium (GPx capacity) Peroxide detox via selenoenzymes Glutathione peroxidases Supports antioxidant enzyme capacity (context-dependent) G Mixed human Narrower safety margin; avoid “more is better” mindset
31 CoQ10 (ubiquinone) ETC electron carrier (I/II→III) + membrane redox Complex I/II→III transfer Supports OXPHOS efficiency; may reduce electron leak under some conditions R, G Limited AD-specific Bioavailability/formulation matters; AD cognition data not robust
32 Cardiolipin / mitochondrial membranes (support axis) ETC supercomplex stability; cristae integrity Inner mitochondrial membrane architecture Membrane integrity affects ETC efficiency and ROS leak G Mechanistic Hard to “target” nutritionally in a clean way; effects indirect
33 Iron / copper homeostasis (burden control) Prevents metal-catalyzed oxidative damage Fenton chemistry burden; metal transport/storage Metal dyshomeostasis can amplify ROS and mitochondrial injury R, G Mechanistic + mixed human “Chelation” is not casually safe; needs careful framing and evidence
41 Ketone utilization (BHB/acetoacetate axis) Alternative brain fuel bypassing glucose bottlenecks MCT1/2 transport; ketolysis enzymes Addresses brain glucose hypometabolism by providing alternate substrate R, G Moderate (human MCI/AD signals exist) GI tolerance and adherence; response varies by genotype/metabolic status
42 Creatine / phosphocreatine shuttle ATP buffering and rapid energy stabilization Creatine kinase system May stabilize energy during stress; supports muscle/functional reserve that impacts cognition indirectly G Limited AD CNS benefit uncertain; stronger for muscle/functional outcomes
43 Acetyl-L-carnitine (ALCAR) Fatty acid oxidation support + acetyl group handling Carnitine shuttle; acetyl-CoA support May support mitochondrial energy and neuronal function (mixed clinical results) R, G Mixed human Benefits heterogeneous; not a universal cognitive improver
44 Medium-chain triglycerides (MCT oil → ketones) Rapid ketone support strategy Hepatic ketogenesis; brain ketone uptake Practical ketone-raising approach for some phenotypes R, G Moderate human GI effects; calorie load; titration matters
51 AMPK → PGC-1α biogenesis axis Mitochondrial number/quality regulation AMPK, PGC-1α, SIRT1 Supports long-term mitochondrial capacity and stress resistance G Mechanistic Most effects are slow; many “activators” are indirect and context-dependent
52 Mitophagy / autophagy quality control Removes damaged mitochondria PINK1/Parkin axis; autophagy machinery Damaged mitochondria drive ROS and energy failure; quality control is protective in theory G Mechanistic Autophagy modulation is double-edged; oversimplified “more autophagy = good” is risky
53 Exercise signaling (the “master cofactor”) Improves vascular + mitochondrial + neurotrophic tone BDNF; insulin sensitivity; AMPK/PGC-1α Most evidence-backed multi-pathway energy intervention for aging brain R, G Strong (human) Adherence/ability constraints; must be individualized
61 Cerebral perfusion / vascular health Fuel + oxygen delivery and waste clearance support Neurovascular unit; endothelial function Vascular dysfunction worsens hypometabolism and inflammation R, G Strong (human) Often upstream of “supplement” efficacy; if delivery is poor, cofactors underperform
62 Sleep / glymphatic clearance Waste clearance & metabolic recovery Glymphatic system; circadian regulation Supports clearance of metabolic byproducts; indirectly supports energy balance G Strong (human) Often neglected; impacts cognition and inflammation strongly
63 Oxygen utilization context (respiratory capacity) Oxidative metabolism support OXPHOS dependence If oxygen delivery/usage is limited, pushing mitochondrial cofactors won’t fully translate R, G Supportive More about system constraints than a “node to supplement”

TSF (Time-Scale Flag): P = 0–30 min, R = 30 min–3 hr, G = >3 hr (adaptation/phenotype). Evidence: "Strong (human)" = consistent clinical/epidemiologic support; "Moderate" = mixed but plausible human signals; "Emerging" = early-stage human; "Mechanistic" = preclinical/biochemical rationale.



Scientific Papers found: Click to Expand⟱
5303- 5-HTP,    5-HTP shows early promise for cognitive support and in seniors: Singapore study
- Trial, AD, NA
*cognitive↑, *Dose↝, *5HT↑,
5298- 5-HTP,    Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa
- Human, AD, NA
*BioAv↑, *Dose↝, *toxicity↝,
5306- 5-HTP,    Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level
- Trial, AD, NA
*cognitive↑, *Dose↝,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3974- ALC,    Carnitine
- Review, AD, NA
*Dose↝, *cognitive↑,
3819- Aroma,    Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
- Human, AD, NA - in-vitro, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *tau↓, *BDNF↑, *motorD↑,
4304- Ba,    Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
- in-vitro, AD, NA
*tau↓, *Dose↝, *BioAv↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
5473- BM,    Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *toxicity∅, *AChE↓, *ROS↓, *antiOx↑, *lipid-P↓, *cognitive↑, *memory↑, *Dose↝, *BioAv↓, *TumCCA↑, *BBB↝,
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
5952- Cela,    Celastrol attenuates Alzheimer’s disease-mediated learning and memory impairment by inhibiting endoplasmic reticulum stress-induced inflammation and oxidative stress
- in-vivo, AD, NA
*memory↑, *Inflam↓, *ROS↓, *ER Stress↓, *neuroP↑, *Dose↝, *MDA↓, *SOD↑, *Catalase↑, *Aβ↓, BACE↓, LRP1↑, RAGE↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
6037- CGA,    Pharmacokinetics and brain penetration study of chlorogenic acid in rats
- in-vivo, AD, NA - in-vivo, Stroke, NA
*Dose↝, *eff↑, *BioAv↑, *eff↑,
6040- CGA,    Protective effect of chlorogenic acid on cognitive impairment in rats with early Alzheimer's disease via Wnt signaling pathway
- in-vivo, AD, NA
*neuroP↑, *Dose↝, *GSK‐3β↓, *tau↓, *β-catenin/ZEB1↑, *Wnt↑, *memory↑, *cognitive↑, *NRF2↑, *ROS↓,
6041- CGA,    Effect of Chlorogenic Acid Intake on Cognitive Function in the Elderly: A Pilot Study
- Trial, AD, NA
*Dose↝, *memory↑, *Risk↓, *cognitive↑, *Aβ↓, *antiOx↓, *motorD↑,
6043- CGA,  SeNPs,    Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro
- in-vitro, AD, NA
*ROS↓, *Aβ↓, *BioAv↝, *BioAv↑, *Dose↝, *ROS↓, *H2O2↓, *toxicity↓,
6001- Chit,    Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks
- Review, Var, HepG2 - Review, AD, NA
TumVol↓, toxicity↓, Half-Life↑, eff↑, selectivity↑, Dose↝, *BDNF↑, *NRF2↑, *ROS↓, *neuroP↑, *memory↑, *cognitive↑, *Obesity↓,
6098- Chol,    Choline
- Review, Nor, NA - Review, AD, NA
*BioAv↝, *Dose↝, *cardioP↑, *BP↓, *cognitive↑, *memory↑, eff∅,
6107- Chol,    Choline supplements: An update
- Review, AD, NA
*memory↑, *cognitive↑, *Dose↝, *BBB↑, *cardioP↑, *ROS↓, *TMAO↑, *memory∅, *eff↑,
6108- Chol,    Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
- Review, Nor, NA - Review, AD, NA
*TMAO↑, *ROS↑, *NADPH↑, *Ca+2↑, *AntiAg↓, *cognitive↓, *TJ↓, *CLDN1↓, *ZO-1↓, *Inflam↑, *NLRP3↑, *ER Stress↑, *cognitive↓, *Dose↝, *eff↑, *other↝, *other↝, *other↝,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP↓, *Dose↝,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3590- CUR,    The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?
- Review, Var, NA - Review, AD, NA
*BioAv↓, *BioAv↑, Dose↑, *Dose↝, *BBB↑, *cognitive↑, *BioAv↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
4290- EGCG,    EGCG impedes human Tau aggregation and interacts with Tau
- in-vitro, AD, NA
*tau↓, *Dose↝, *neuroP↑, *antiOx↑,
6049- EGCG,  SeNPs,    Epigallocatechin-3-gallate (EGCG)-stabilized selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-β aggregation and cytotoxicity
- Study, AD, PC12
*Aβ↓, *Dose↝, *BioAv↑, *ROS↓,
4075- FA,    Folic acid, ageing, depression, and dementia
- Review, AD, NA
*Mood↑, *cognitive↑, *other↝, *memory↑, *QoL↑, *homoC↝, *other↝, *Dose↝,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
3721- Gb,    Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice
- Review, AD, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,
4307- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *neuroP↑, *memory↑, *BBB↑, *BDNF↑, *TNF-α↓, *Catalase↑, *IL6↓, *Aβ↓, *GABA↓, *Dose↝,
4308- H2,    A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy
- in-vivo, AD, NA
*BioAv↝, *ROS↓, *p‑tau↓, *Dose↝, *cognitive↑,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1↓, *FASN↓, *ACC↓,
2385- MET,    Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model
- in-vitro, AD, H4 - in-vitro, NA, HEK293 - in-vivo, NA, NA - in-vitro, NA, SH-SY5Y
*HK2↓, *PKM2↓, *Dose↝, IKKα↑, memory↑, p‑Hsc70↑, APP↓,
4096- MF,    Extremely Low‐Frequency and Low‐Intensity Electromagnetic Field Technology (ELF‐EMF) Sculpts Microtubules
- in-vitro, AD, NA
*p‑tau↓, *neuroP↑, *Dose↝,
4119- MF,    Therapeutic potential and mechanisms of repetitive transcranial magnetic stimulation in Alzheimer’s disease: a literature review
- Review, AD, NA
*cognitive↑, *memory↑, *motorD↑, *eff↑, *eff↑, *Dose↝, *Dose↝, *Dose↝, *BDNF↑, *Aβ↓, *eff↑,
3740- MF,    Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *PSD95↑,
2484- mushLions,    Neurotrophic and Neuroprotective Effects of Hericium erinaceus
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
3916- PS,    The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study
- Human, AD, NA
*memory↑, *cognitive↑, *BP↓, *Dose↝, *eff↑,
6054- RES,  SeNPs,    Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *Aβ↓, *ROS↓, *TAC↑, *GutMicro↑, *BBB↑,
3621- RosA,    Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population
- Trial, AD, NA
*cognitive↑, *Dose↝, *BioAv↑,

Showing Research Papers: 1 to 50 of 69
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 69

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NOX4↓, 1,   ROS↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ETC↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Casp↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   FasL↑, 1,   JNK↑, 2,   MAPK↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   p‑Hsc70↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↝, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   APP↓, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 1,   RAGE↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 2,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

P-gp⇅, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↓, 1,   IKKα↑, 1,   Inflam↓, 2,   NF-kB↓, 1,   PGE2↓, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   Dose↑, 1,   Dose↝, 3,   eff↑, 1,   eff∅, 1,   Half-Life↑, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 1,   radioP↑, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 67

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TMAO↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 11,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 6,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GSH↑, 7,   GSR↑, 1,   H2O2↓, 1,   H2O2∅, 1,   HDL↑, 1,   HO-1↑, 6,   lipid-P↓, 7,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 9,   RNS↓, 1,   ROS?, 1,   ROS↓, 27,   ROS↑, 1,   SOD↑, 10,   TAC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 5,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,   MMP↑, 3,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ALAT↓, 2,   AMPK↑, 2,   FASN↓, 1,   GlucoseCon↑, 1,   HK2↓, 1,   homoC↝, 1,   LDH↑, 1,   LDL↓, 2,   NADPH↑, 1,   PKM2↓, 1,   PPARγ↑, 2,   SIRT1↑, 2,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   BAX↓, 3,   Bcl-2↑, 1,   Casp3↓, 2,   cl‑Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   p‑MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 3,   other↝, 8,   other∅, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 3,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   ERK↑, 1,   GSK‐3β↓, 2,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↓, 1,   STAT3↓, 1,   Wnt↑, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↓, 1,   AP-1↓, 1,   Ca+2↓, 3,   Ca+2↑, 1,   CDK5↓, 1,   CLDN1↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 5,   PKCδ↑, 1,   ROCK1↓, 1,   TJ↓, 1,   VCAM-1↓, 3,   ZO-1↓, 1,   β-catenin/ZEB1↑, 1,  

Barriers & Transport ⓘ

BBB↑, 13,   BBB↝, 1,   GLUT4↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 6,   CRP↓, 2,   CXCR4↓, 1,   ICAM-1↓, 3,   IL10↑, 1,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 6,   IL22↓, 1,   IL4↑, 1,   IL6↓, 9,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 10,   Inflam↑, 1,   NF-kB↓, 6,   NF-kB↑, 1,   PGE2↓, 5,   TNF-α↓, 11,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 5,   BChE↓, 1,   BDNF↑, 6,   ChAT↑, 1,   GABA↓, 1,   MAOA↓, 1,   PSD95↑, 1,   tau↓, 6,   p‑tau↓, 4,  

Protein Aggregation ⓘ

Aβ↓, 13,   BACE↓, 2,   MAOB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   β-Amyloid↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 6,   BioAv↑, 14,   BioAv↝, 8,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 50,   eff↑, 21,   eff↝, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   AST↓, 2,   BG↓, 1,   Bil↑, 1,   BP↓, 3,   BP↝, 1,   creat↓, 1,   CRP↓, 2,   GutMicro↑, 5,   IL6↓, 9,   Ki-67↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 5,   cognitive↓, 2,   cognitive↑, 29,   hepatoP↑, 5,   memory↑, 18,   memory∅, 1,   Mood↑, 1,   motorD↑, 3,   neuroP↑, 22,   Obesity↓, 1,   OS↑, 1,   QoL↑, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 4,  
Total Targets: 186

Scientific Paper Hit Count for: Dose, Dosage
8 Selenium NanoParticles
6 Chlorogenic acid
4 Curcumin
3 5-Hydroxytryptophan
3 Choline
3 Magnetic Fields
2 Baicalein
2 Berberine
2 Boswellia (frankincense)
2 Celastrol
2 chitosan
2 EGCG (Epigallocatechin Gallate)
2 Folic Acid, Vit B9
2 Hydrogen Gas
2 Resveratrol
2 Rosmarinic acid
2 Spermidine
2 Urolithin
2 Vitamin B1/Thiamine
2 Vitamin B5,Pantothenic Acid
2 Vitamin E
1 Alpha-Lipoic-Acid
1 Acetyl-l-carnitine
1 Aromatherapy
1 Baicalin
1 Biochanin A
1 Bacopa monnieri
1 borneol
1 Coenzyme Q10
1 Selenium
1 Calorie Restriction Mimetics
1 Crocetin
1 Ferulic acid
1 Shilajit/Fulvic Acid
1 Ginkgo biloba
1 Huperzine A/Huperzia serrata
1 Lycopene
1 Metformin
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Phosphatidylserine
1 Silymarin (Milk Thistle) silibinin
1 Selenite (Sodium)
1 Taurine
1 Vitamin B6,pyridoxine
1 Vitamin B12
1 Vitamin D3
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:38  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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