mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
242- Api,    Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, C8161
ERK↓, PI3k/Akt/mTOR↓, Casp3↑, PARP↑, p‑mTOR↓, p‑Akt↓,
2849- FIS,    Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7552- HYP,    Hyperoside exerts potent anticancer activity in skin cancer
- vitro+vivo, Melanoma, NA
AntiCan↑, *Inflam↓, *antiOx↑, PI3K↓, Akt↓, mTOR↓, TumCP↓, Apoptosis↑, TumAuto↑, chemoPv↑,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
8106- KAE,    Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway
- in-vitro, Melanoma, A375
Apoptosis↑, TumCCA↑, TumCMig↓, mTOR↓, PI3K↓, Akt↓,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 1,   PI3k/Akt/mTOR↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 2,   Apoptosis↑, 4,   BAD↑, 1,   BAX↑, 4,   Bcl-2↓, 4,   BIM↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   p‑MAPK↓, 1,   Mcl-1↓, 1,   survivin↓, 2,   TumCD↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↓, 2,   mTOR↓, 5,   p‑mTOR↓, 3,   PI3K↓, 5,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↓, 2,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoPv↑, 1,  
Total Targets: 58

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
1 1,8-Cineole
1 Apigenin (mainly Parsley)
1 Fisetin
1 Ginger/6-Shogaol/Gingerol
1 Hyperoside
1 Isoliquiritigenin
1 isoquercitrin
1 Kaempferol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page