ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
206- Api,    Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, Melanoma, A375 - in-vitro, Lung, H2030 - in-vitro, CRC, SW480
Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,
6129- CHr,    A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
- vitro+vivo, Melanoma, NA
ATP↓, TumCCA↑, CDK2↓, CDK4↓, TumW↓,
5010- DSF,  Cu,  Rad,    Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma
- in-vivo, Melanoma, B16-F10
Apoptosis↑, ICD↑, HMGB1↑, ATP↓, TumCG↓,
8089- KAE,    Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, B16-F10
TumCMig↓, TumCI↓, TumMeta↓, ECAR↓, GlucoseCon↓, ATP↓, Pyruv↓, lactateProd↓, HK2↓, VDAC1↓, Akt↓, GSK‐3β↝, Glycolysis↓,
8162- LapC,    Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- in-vitro, Melanoma, MEL526 - in-vitro, Melanoma, MEL697 - in-vitro, Melanoma, MEL103
Glycolysis↓, OCR↑, PKM2↓, ATP↓, TumCP↓, Apoptosis↑, OXPHOS↑, Dose↝,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HK1↓, 1,   ICD↑, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   OXPHOS↑, 1,   ROS↑, 2,   SOD↓, 1,   VDAC1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 6,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALDOA↓, 1,   ECAR↓, 1,   ENO1↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 2,   LDH↓, 1,   NADPH↓, 1,   PGK1↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPP↓, 1,   Pyruv↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Casp3↑, 1,   Casp9↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↝, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   HMGB1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumW↓, 1,  
Total Targets: 50

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
1 Apigenin (mainly Parsley)
1 Chrysin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Radiotherapy/Radiation
1 Kaempferol
1 Lapachol
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:21  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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