HDAC3 Cancer Research Results

HDAC3, Histone Deacetylase 3: Click to Expand ⟱
Source:
Type:
HDAC3 is an enzyme belonging to the class I histone deacetylases and plays a key role in transcriptional regulation by removing acetyl groups from histone tails.
This deacetylase activity leads to chromatin condensation and generally results in transcriptional repression.
HDAC3 is involved in multiple cellular processes, including cell cycle regulation, apoptosis, and differentiation.

HDAC3 is frequently found to be overexpressed in several cancer types, including breast, colorectal, liver, lung, and hematological malignancies.
Elevated HDAC3 levels have been associated with the repression of tumor suppressor genes and deregulation of proliferative pathways.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1430- SFN,    Sulforaphane bioavailability and chemopreventive activity in women scheduled for breast biopsy
- Trial, BC, NA
*HDAC3↓, HDAC↓, *toxicity↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   HK2↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   hTERT/TERT↓, 1,   p27↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMTs↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 1,   HMTs↓, 1,   KLF4↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

HDAC3↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: HDAC3, Histone Deacetylase 3
3 Sulforaphane (mainly Broccoli)
1 Genistein (soy isoflavone)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1023  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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