TLR2 Cancer Research Results

TLR2, Toll-Like Receptor 2: Click to Expand ⟱
Source:
Type:
TLR2 is a member of the Toll-like receptor (TLR) family, which plays a key role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). TLR2 is unique in its ability to form heterodimers with other TLRs (such as TLR1 and TLR6) to broaden its ligand specificity.

TLR2 is often described as having a “double-edged sword” role. On one side, stimulation of TLR2 can enhance the immune system’s ability to detect and destroy tumor cells. On the other side, persistent TLR2 signaling may lead to a pro-tumorigenic environment characterized by the secretion of growth factors, angiogenic signals, and immune suppressive cytokines that facilitate tumor progression.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
2210- SK,    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway
- in-vitro, BC, MGC803
TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Migration ⓘ

MMP2↓, 1,   MMP7↓, 1,   TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   p65↓, 1,   TLR2↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TLR2, Toll-Like Receptor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1042  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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