ERK Cancer Research Results

ERK, ERK signaling: Click to Expand ⟱
Source:
Type:
MAPK3 (ERK1)
ERK proteins are kinases that activate other proteins by adding a phosphate group. An overactivation of these proteins causes the cell cycle to stop.
The extracellular signal-regulated kinase (ERK) signaling pathway is a crucial component of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in regulating various cellular processes, including proliferation, differentiation, and survival. high levels of phosphorylated ERK (p-ERK) in tumor samples may indicate active ERK signaling and could correlate with aggressive tumor behavior

EEk singaling is frequently activated and is often associated with aggressive tumor behavior, treatment resistance, and poor outcomes.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
382- AgNPs,    Investigation the apoptotic effect of silver nanoparticles (Ag-NPs) on MDA-MB 231 breast cancer epithelial cells via signaling pathways
- in-vitro, BC, MDA-MB-231
Apoptosis↑, BAX↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, p‑ERK↓, cycD1/CCND1↓,
253- AL,    Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α
- in-vitro, BC, MDA-MB-231
TumCMig↓, ERK↓, VCAM-1↓, NF-kB↓,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
2694- BBR,    Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells
- in-vitro, BC, NA
IL8↓, TumCI↓, EGFR↓, MEK↓, ERK↓, TGF-β1↓, VEGF↓,
1473- BCA,  SFN,    An Insight on Synergistic Anti-cancer Efficacy of Biochanin A and Sulforaphane Combination Against Breast Cancer
- in-vitro, BC, MCF-7
eff↑, ROS↑, other↑, ERK↓, Apoptosis↑,
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF-7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,
6066- CHL,    The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion
- in-vitro, BC, MCF-7
ERK↓, Bcl-2↓, Apoptosis↑,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
1446- Deg,    Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
- in-vitro, BC, 4T1
cMET↓, p‑ERK↓, p‑Akt↓, TumCMig↓, TumCG↓, Weight∅, *toxicity∅, Hif1a↓, TumMeta↓,
1109- DHA,    DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells
- in-vitro, BC, NA
GREM1↓, TumCMig↓, p‑ERK↓, EMT↓,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
1059- PI,    Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2
EMT↓, p‑ERK↓, p‑SMAD2↓,
3084- RES,    Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D
TumCP↓, EZH2↓, p‑ERK↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
1210- SANG,    Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer
- in-vitro, BC, NA
EphB4↓, Hif1a↓, STAT3↓, MAPK↓, ERK↓,
1090- SANG,    Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
- in-vitro, BC, MCF-7
MMP9↓, COX2↓, PGE2↓, NF-kB↓, AP-1↓, p‑Akt↓, p‑ERK↓, HO-1↑,
1499- SFN,    Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, FAK↓, p‑MEK↓, p‑ERK↓,
3305- SIL,    Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vivo, NA, NA
TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,
1276- SIL,    Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells
- in-vitro, BC, NA - in-vitro, Thyroid, NA
TumCMig↓, MMP9↓, p‑MEK↓, p‑ERK↓,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,

Showing Research Papers: 1 to 20 of 20

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 20

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   lipid-P↓, 1,   NRF2↝, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MEK↓, 1,   p‑MEK↓, 2,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   FASN↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 2,   Apoptosis↑, 5,   BAX↑, 2,   BAX↝, 1,   Bcl-2↓, 4,   Casp9↑, 1,   hTERT/TERT↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   Myc↓, 1,   p‑p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   other↑, 1,   tumCV↓, 2,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,   P53↝, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD24↓, 1,   cMET↓, 2,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 10,   p‑ERK↓, 10,   GREM1↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   mTOR↓, 1,   PTEN↑, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 3,  

Migration ⓘ

AP-1↓, 1,   EphB4↓, 1,   FAK↓, 2,   Furin↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MMP9↓, 4,   p‑SMAD2↓, 1,   TGF-β1↓, 1,   TumCI↓, 2,   TumCMig↓, 5,   TumCP↓, 3,   TumMeta↓, 1,   VCAM-1↓, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 2,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 6,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 2,   EZH2↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,   Weight∅, 1,  
Total Targets: 87

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 1,   toxicity∅, 2,  
Total Targets: 4

Scientific Paper Hit Count for: ERK, ERK signaling
2 Sulforaphane (mainly Broccoli)
2 Deguelin
2 Resveratrol
2 Sanguinarine
2 Silymarin (Milk Thistle) silibinin
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Berberine
1 Biochanin A
1 Caffeic acid
1 Zinc
1 Radiotherapy/Radiation
1 Chlorophyllin
1 Docosahexaenoic Acid
1 Lycopene
1 Piperine
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:105  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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