Pin1 Cancer Research Results

Pin1, Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1: Click to Expand ⟱
Source:
Type:
Pin1 (Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1) is a peptidyl-prolyl isomerase that specifically recognizes phosphorylated serine/threonine-proline motifs, thereby modulating the conformation and function of various proteins. This post-phosphorylation regulation can directly affect cell division, survival, and metastasis—all of which impact cancer progression.

High Pin1 expression in breast, pca, had and lung cancers is associated with more aggressive tumor behavior, increased metastatic potential, and poorer overall survival.

Inhibitors:
-Juglone (5-hydroxy-1,4-naphthoquinone) is one of the most widely studied natural inhibitors of Pin1.
-All‑trans Retinoic Acid (ATRA).
A metabolite of vitamin A, ATRA has been reported to inhibit Pin1 activity.
-EGCG
-Curcumin (Proposed)

Juglone is thought to act via direct covalent modifications of Pin1, whereas ATRA and EGCG likely interact through non-covalent binding.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
7961- JG,    Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, 4T1 - vitro+vivo, CRC, HCT116
EMT↓, CSCs↓, TumMeta↓, Pin1↓, TumCCA↑, angioG↓, Apoptosis↑, BAX↑, Bcl-2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,  

Migration(tgid=13) ⓘ

TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Pin1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Pin1, Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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