TXNIP Cancer Research Results

TXNIP, TBP-2: Click to Expand ⟱

Source:

Type:

TXNIP {TBP-2 (Thioredoxin Binding Protein-2)} is broadly considered a tumor suppressor, given its roles in redox regulation, apoptosis, and cellular metabolism.
- Thioredoxin‐interacting protein (TXNIP), which belongs to the arrestin family and is induced by various stimuli, interacts with and inhibits thioredoxin activity.

- Lower TXNIP expression has been correlated with more aggressive disease features and poorer prognosis, while higher expression tends to associate with less aggressive phenotypes.
- A consistent theme across these cancers is that lower TXNIP expression frequently correlates with more aggressive disease and a worse prognosis.

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

2456-

MET,

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

GlucoseCon↓, TumCG↓, HK2↓, p‑AMPK↑, TXNIP↓, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1, GlucoseCon↓, 1, HK2↓, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Migration ⓘ

TXNIP↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Functional Outcomes ⓘ

toxicity↓, 1,
Total Targets: 1

Scientific Paper Hit Count for: TXNIP, TBP-2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1237  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid