GLO-I Cancer Research Results

GLO-I, glyoxalase I: Click to Expand ⟱

Source:

Type:

GLO-I, or glyoxalase I, is an enzyme that plays a crucial role in the detoxification of reactive carbonyl species, particularly methylglyoxal, which is a byproduct of various metabolic processes.
-Glyoxalase-I (Glo-I) and glyoxalase-II (Glo-II) comprise the glyoxalase system and are responsible for the detoxification of methylglyoxal (MGO). MGO is formed non-enzymatically as a by-product, mainly in glycolysis, and leads to the formation of advanced glycation endproducts (AGEs).
-Elevated levels of GLO-I in cancer cells can help them cope with these toxic byproducts, promoting cell survival and proliferation.
-High levels of GLO-I may be associated with tumor progression and poor prognosis in certain types of cancer.
-Inhibiting GLO-I could sensitize cancer cells to chemotherapy and other treatments by increasing their vulnerability to oxidative stress.
-Many studies have reported that GLO-I is overexpressed in several types of cancers, including breast, lung, prostate, colorectal, and pancreatic cancers. This overexpression is often associated with aggressive tumor behavior and poor prognosis.
Inhibitors: – Several flavonoids such as quercetin, luteolin, and fisetin have been shown to inhibit glyoxalase I activity in enzyme assays. - Curcumin. - Resveratrol - EGCG

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

409-

CUR,

Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity

in-vitro,

Pca,

PC3

7.9 µM

in-vitro,

BC,

MDA-MB-231

GLO-I↓, GSH↓, ATP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSH↓, 1,

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,

Core Metabolism/Glycolysis ⓘ

GLO-I↓, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GLO-I, glyoxalase I

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells