DNMT3B Cancer Research Results

DNMT3B, Maintenance DNA Methyltransferase: Click to Expand ⟱
Source:
Type: oncogenic
DNMT3B 
Often UPREGULATED (mainly solid tumors)
Effect
-Aberrant de novo methylation at non-physiologic loci
-Silencing of differentiation and tumor suppressor genes
-Reinforces epigenetic chaos rather than orderly programming

Classification
-Contextual oncogenic epigenetic amplifier


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
7654- IP,    Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations
- in-vivo, BC, NA
TumCG↓, GutMicro↑, PA↑, HDAC2↓, HDAC8↓, DNMT3B↓, Akt↓, PI3K↓, NF-kB↓, Dose↝, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PA↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT3B↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC2↓, 1,   HDAC8↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DNMT3B, Maintenance DNA Methyltransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1409  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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