FOXM1 Cancer Research Results

FOXM1, FOXM1 transcription factor: Click to Expand ⟱
Source:
Type:
FOXM1 transcription factor is a regulator of a broad range of biological processes.
Master Driver of Proliferation, Genomic Instability, and Therapy Resistance
Elevated and deregulated FOXM1 expression is found in a wide spectrum of cancers. FOXM1 also plays a central role in cancer initiation, progression and anti-cancer drug resistance. FOXM1 is repeatedly overexpressed in a variety of human cancers.
High FOXM1 expression is associated with aggressive tumor characteristics and poor overall survival. FOXM1 is generally considered a marker of poor prognosis across various cancer types.
FOXM1 is used as a clinical biomarker for Epigentic instability


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1348- And,    Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vivo, NA, NA
ERα/ESR1↓, TumCG↓, ROS↑, FOXM1↓, eff↑,
8149- lamb,    Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, TumCCA↑, AMPK↑, Akt↓, FOXM1↓, Bcl-2↓, CycB/CCNB1↓, APOE4↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APOE4↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bcl-2↓, 1,   TumCD↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXM1↓, 2,   TumCG↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ERα/ESR1↓, 1,   FOXM1↓, 2,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FOXM1, FOXM1 transcription factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:351  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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