EphB4 Cancer Research Results

EphB4, tyrosine kinase EphB4: Click to Expand ⟱
Source:
Type:
Eph receptors and their Eph receptor-interacting (ephrin) ligands together form an important cell communication system with diverse roles.
High EPHB4 expression correlates with advanced prostate cancer stage and poor outcome.
EphB4 is often upregulated in cancer, and its expression may be linked to tumor progression and poor prognosis.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1210- SANG,    Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer
- in-vitro, BC, NA
EphB4↓, Hif1a↓, STAT3↓, MAPK↓, ERK↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration ⓘ

EphB4↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EphB4, tyrosine kinase EphB4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:398  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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