VCAM-1 Cancer Research Results

VCAM-1, Vascular cell adhesion protein 1: Click to Expand ⟱
Source:
Type:
A protein that in humans is encoded by the VCAM1 gene.
VCAM-1 is a cell surface glycoprotein primarily expressed by activated endothelial cells.
It mediates adhesion of leukocytes and plays a key role in inflammation and immune cell trafficking.
In the tumor microenvironment, VCAM-1 is often upregulated and is involved in the interactions between tumor cells, immune cells, and the vasculature.

VCAM-1 is predominantly protumorigenic in cancer contexts. Its upregulation in tumor tissues and vasculature contributes to enhanced tumor cell adhesion, migration, and metastasis, and correlates with poor clinical outcomes.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
253- AL,    Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α
- in-vitro, BC, MDA-MB-231
TumCMig↓, ERK↓, VCAM-1↓, NF-kB↓,
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF-7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 2,  

Migration ⓘ

TumCMig↓, 1,   VCAM-1↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 2,  

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: VCAM-1, Vascular cell adhesion protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:420  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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