PGK1 Cancer Research Results

PGK1, Phosphoglycerate kinase 1: Click to Expand ⟱

Source:

Type:

Phosphoglycerate kinase 1 (PGK1) is the first critical enzyme to produce ATP in the glycolytic pathway. PGK1 is not only a metabolic enzyme but also a protein kinase, which mediates the tumor growth, migration and invasion through phosphorylation some important substrates.
PGK1 expression was shown to be significantly upregulated in multiple cancer tissues.

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

933-

CUR,

EP,

Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study

in-vitro,

BC,

50uM, 1200v/c,100us

Apoptosis↑, ALDOA↓, ENO2↓, LDHA↓, LDHB↓, PFKP↓, PGK1↓, PGM1↓, PGAM1↓, OXPHOS↑, TCA↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,

Core Metabolism/Glycolysis ⓘ

ALDOA↓, 1, ENO2↓, 1, LDHA↓, 1, LDHB↓, 1, PFKP↓, 1, PGAM1↓, 1, PGK1↓, 1, PGM1↓, 1, TCA↑, 1,

Cell Death ⓘ

Apoptosis↑, 1,
Total Targets: 11

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PGK1, Phosphoglycerate kinase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells