cFos Cancer Research Results

cFos, cellular Fos: Click to Expand ⟱
Source:
Type:
c-Fos is an immediate early gene that encodes a protein involved in various cellular processes, including cell proliferation, differentiation, and survival. It is part of the Fos family of proteins, which are transcription factors that can regulate the expression of other genes. Increased expression of c-Fos is often associated with more aggressive tumor behavior and poorer prognosis across various cancer types. Its role as an immediate early gene suggests that it may be involved in the early response to oncogenic signals, contributing to tumor development and progression.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   CREB2↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: cFos, cellular Fos
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:479  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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