EPR Cancer Research Results

EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱

Source:

Type:

Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

992-

PL,

Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1

in-vivo,

BC,

zebrafish and nude mice

EPR↓, Glycolysis↓, GAPDH↓, GSTP1/GSTπ↝, FBPase↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSTP1/GSTπ↝, 1,

Core Metabolism/Glycolysis ⓘ

FBPase↑, 1, GAPDH↓, 1, Glycolysis↓, 1,

Angiogenesis & Vasculature ⓘ

EPR↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells