ALDH Cancer Research Results

ALDH, Aldehyde Dehydrogenase: Click to Expand ⟱
Source:
Type:
ALDH (Aldehyde Dehydrogenase) is a family of enzymes that play a crucial role in various cellular processes, including detoxification, differentiation, and cell survival. In the context of cancer, ALDH has been implicated in several aspects of tumor biology.

ALDH enzymes are involved in the metabolism of aldehydes, which are toxic compounds that can damage cellular components. In cancer cells, ALDH enzymes can help to detoxify these compounds, promoting cell survival and resistance to chemotherapy.

There are 19 different ALDH isoforms, and each has a distinct expression pattern in cancer. Some isoforms, such as ALDH1A1 and ALDH1A3, are more commonly associated with cancer stem cells, while others, such as ALDH2, are more widely expressed in cancer cells.

Highly Expressed: Brain, overian, prostate, pancreatic, liver, stomach, esophageal, head and neck, melanoma, ALL, CML
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
5216- PI,  doxoR,    Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells
- vitro+vivo, BC, MDA-MB-231
ChemoSen↑, necrosis↑, PTEN↓, PI3K↓, p‑Akt↓, mTOR↓, ALDH↓, TumVol↓, OS↑, cardioP↑, cl‑PARP↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   mitResp↓, 1,   MMP↓, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   cMyc↓, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   NAD↓, 1,   PFK↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   Apoptosis∅, 1,   Bcl-2↓, 1,   Myc↓, 1,   necrosis↑, 2,   p27↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,  

Autophagy & Lysosomes ⓘ

LC3B-II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   p‑P53↑, 1,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   P21↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 4,   CD24↓, 1,   CD44↓, 2,   CSCs↓, 3,   Gli1↓, 1,   GSK‐3β↓, 1,   mTOR↓, 3,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PTCH1↓, 1,   PTEN↓, 1,   Smo↓, 1,   SOX2↓, 1,   TumCG↓, 2,   TumCG↑, 1,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 1,   GLI2↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   eff↓, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   OS↑, 1,   TumVol↓, 1,  
Total Targets: 71

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ALDH, Aldehyde Dehydrogenase
2 salinomycin
1 Alpha-Lipoic-Acid
1 Piperine
1 doxorubicin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:676  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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