MMP3 Cancer Research Results

MMP3, Matrix metalloproteinase-3: Click to Expand ⟱
Source:
Type:
MP-3: also known as stromelysin-1, is a type of enzyme that plays a crucial role in the degradation of the extracellular matrix (ECM).
MMP-3 can break down the ECM, allowing cancer cells to invade surrounding tissues and form new tumors.
High levels of MMP-3 expression are associated with poor prognosis in various types of cancer, including breast, lung, and colon cancer.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 2,   ROS↑, 1,   SIRT3↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 2,   LDHA↓, 1,   PKM2↓, 1,   PPARα↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   mt-Apoptosis↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp3↑, 2,   Casp6↑, 1,   Casp9↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B-II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   MMP2↓, 1,   MMP3↓, 3,   MMP9↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   eff↓, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 48

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   neuroP↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: MMP3, Matrix metalloproteinase-3
1 Carvacrol
1 Kaempferol
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:757  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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