GAPDH Cancer Research Results

GAPDH, Glyceraldehyde-3-phosphate dehydrogenase: Click to Expand ⟱
Source:
Type: gene
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a housekeeping gene that encodes a protein involved in glycolysis, a metabolic pathway that converts glucose into energy. GAPDH is a crucial enzyme in the glycolytic pathway, and its expression is often used as a control gene in molecular biology experiments.
GAPDH has been shown to be overexpressed in various types of tumors, including breast, lung, colon, and prostate cancer.
Cancer cells often exhibit increased glycolysis, even in the presence of oxygen, a phenomenon known as the Warburg effect. GAPDH overexpression can contribute to this increased glycolysis.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
694- EGCG,    Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways
- in-vitro, BC, MCF-7
Glycolysis↓, GAPDH↓, ROS↑, OCR↓, ECAR↓, mTOR↓, OXPHOS↓,
992- PL,    Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1
- in-vivo, BC, NA
EPR↓, Glycolysis↓, GAPDH↓, GSTP1/GSTπ↝, FBPase↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSTP1/GSTπ↝, 1,   OXPHOS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 2,   FBPase↑, 1,   GAPDH↓, 3,   Glycolysis↓, 3,   PPP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Angiogenesis & Vasculature ⓘ

EPR↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   RadioS↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GAPDH, Glyceraldehyde-3-phosphate dehydrogenase
1 3-bromopyruvate
1 Radiotherapy/Radiation
1 EGCG (Epigallocatechin Gallate)
1 Piperlongumine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:812  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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