COL1A1 Cancer Research Results

COL1A1, Collagen Type I Alpha 1 Chain: Click to Expand ⟱

Source:

Type: gene/protein

COL1A1 (Collagen Type I Alpha 1 Chain) is a gene that encodes for a protein that is a component of type I collagen, a major structural protein found in the extracellular matrix of connective tissue.
COL1A1 has been shown to promote tumor growth, invasion, and metastasis by facilitating cell adhesion, migration, and angiogenesis.

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

756-

Bor,

Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells

in-vitro,

BC,

MCF-7

45.69 mM

However, it cannot be said that it improves the metastasis properties of breast cancer stem cells.

COL1A1↓, Vim↓, miR-127-5p↑, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑,

736-

Bor,

Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells

in-vitro,

BC,

MCF-7

45.69 mM

miR-126↑, COL1A1↓, Vim↓, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑, miR-127-5p↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

miR-127-5p↑, 2,

Migration ⓘ

CDH1↑, 2, COL1A1↓, 2, ITGA5↑, 2, ITGB1↑, 2, LAMA5↑, 2, Snail↑, 2, Vim↓, 2, Zeb1↑, 2,

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: COL1A1, Collagen Type I Alpha 1 Chain

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells