cFLIP Cancer Research Results

cFLIP, cellular FLICE-like inhibitory protein: Click to Expand ⟱
Source:
Type: protein
c-FLIP (cellular FLICE-like inhibitory protein) also know as FLIP
- is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death.
It is a key regulator of the extrinsic pathway of apoptosis, which is mediated by death receptors such as Fas and TNF-R1.
c-FLIP is a pseudokinase that can inhibit the activation of caspase-8, a key enzyme in the extrinsic pathway of apoptosis. By inhibiting caspase-8 activation, c-FLIP can prevent the initiation of the apoptotic cascade and promote cell survival.
In cancer, c-FLIP is often overexpressed, which can contribute to the development and progression of the disease.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 1,   DR5↑, 1,   survivin↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

eff↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: cFLIP, cellular FLICE-like inhibitory protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:885  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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