Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
4364- AgNPs,    Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties
- in-vitro, BC, MCF7
TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,
4818- ASTX,  MEL,    Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
6651- Cen,    Study of the cytotoxicity of asiaticoside on rats and tumour cells
- vitro+vivo, BC, MCF7
Casp3↑, TNF-α↓, IL1β↓, Apoptosis↑, TumCCA↑, TumVol↓, radioP↑, Inflam↓,
6641- Cen,    Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
- in-vitro, BC, MCF7
Casp9↑, TNF-α↓, IL6↓, NF-kB↓, TumCG↓, Inflam↓, TumCP↓, EMT↓,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
6383- Eug,    In Vitro Incorporation of Radioiodinated Eugenol on Adenocarcinoma Cell Lines (Caco2, MCF7, and PC3)
- in-vitro, Colon, Caco-2 - in-vitro, BC, MCF7 - in-vitro, Pca, PC3
antiOx↑, Inflam↓, AntiCan↓, other↝, BioAv↑, other↝,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2888- HNK,    Honokiol mediated inhibition of PI3K/mTOR pathway: A potential strategy to overcome immunoresistance in glioma, breast and prostate carcinoma without impacting T cell function
- in-vitro, Var, PC3 - in-vitro, BC, BT549
PI3K↓, mTOR↓, Inflam↓,
7568- HYP,  PacT,    Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, selectivity↑, chemoP↑, TumCI↓, ChemoSen↑, tumCV↓, Apoptosis↑, Casp3↑, TLR4↓, NF-kB↓,
7550- HYP,    Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway
- in-vitro, BC, MCF7 - in-vitro, BC, 4T1
*Inflam↓, AntiCan↑, tumCV↓, TumCMig↓, Apoptosis↑, Bcl-2↓, XIAP↓, BAX↑, cl‑Casp3↑, ROS↓, NF-kB↓, TumVol↓,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7672- iod,    Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study
- Trial, BC, NA
Dose↝, OS↑, TumCI↓, Apoptosis↑, EstroRS/ERS↑, eff↑, *cardioP↑, *antiOx↑, *Inflam↓,
7756- ISL,    Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
AntiCan↑, VEGF↓, TumCI↓, TumCMig↓, Hif1a↓, TumCG↓, angioG↓, VEGFR2/KDR/Flk1↓, Apoptosis↑, toxicity↓, TumCCA↑, Inflam↓, ROS↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,
8208- LCA,    Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells
- in-vitro, BC, MCF7
*Inflam↓, *AntiCan↑, *AntiP↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, Casp3↑, Bcl-2↓, TumAuto↑, Apoptosis↑, tumCV?,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1669- PBG,  Chemo,    Antioxidant and anti-inflammatory effects of oral propolis in patients with breast cancer treated with chemotherapy: a Randomized controlled trial
- Trial, BC, NA
antiOx↑, Inflam↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3305- SIL,    Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,
1191- SM,    Salvia miltiorrhiza extract inhibits TPA‑induced MMP‑9 expression and invasion through the MAPK/AP‑1 signaling pathw
- in-vitro, BC, MCF7
Inflam↓, MMP9↓, TumCI↓, AP-1↓, lipidLev↓,
5087- SSE,    Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System
- Trial, BC, NA
eff↑, Inflam↓, Imm↑, ROS↑, *NK cell↑,
4842- Uro,    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MCF7 - in-vitro, BC, 4T1
Inflam↓, IL6↓, TNF-α↓, eff↑, STAT3↓, TumCP↓, TumCMig↓,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,   DHODH↓, 1,   PRKCQ/PKCθ↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   HO-1↑, 1,   NRF2↑, 2,   ROS↓, 1,   ROS↑, 14,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   MMP↓, 7,   MPT↑, 1,   mtDam↑, 4,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   LDH↓, 3,   lipidLev↓, 1,   PFK↓, 2,   PKM2↓, 1,   POLD1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 10,   BAX↓, 1,   BAX↑, 5,   Bcl-2↓, 9,   Bcl-xL↓, 1,   Casp3↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 2,   hTERT/TERT↓, 1,   iNOS↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   MOMP↓, 1,   necrosis↑, 1,   p‑p38↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV?, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 2,   ER Stress↑, 3,   GRP78/BiP?, 1,   GRP78/BiP↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↑, 2,   p62↓, 2,   SESN2↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   TP53↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 1,   TumCCA↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   Diff↑, 1,   EMT↓, 3,   p‑ERK↓, 1,   FOXO4↓, 1,   Gli1↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1↓, 1,   miR-34a↑, 1,   mTOR↓, 3,   PI3K↓, 3,   PTCH1↓, 1,   Shh↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   E-cadherin↑, 1,   FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 3,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP2↑, 1,   TumCI↓, 7,   TumCMig↓, 6,   TumCP↓, 6,   TumMeta↓, 1,   Vim?, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   eNOS↑, 1,   Hif1a↓, 3,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   IL10↓, 2,   IL1β↓, 3,   IL4↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 15,   NF-kB↓, 6,   p65↓, 1,   PD-1↓, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

EstroRS/ERS↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 4,   ChemoSen↓, 1,   ChemoSen↑, 4,   Dose↓, 1,   Dose↝, 2,   Dose∅, 2,   eff↑, 13,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   EstroRS/ERS↑, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 1,   LDH↓, 3,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 5,   AntiTum↑, 3,   chemoP↑, 2,   OS↑, 2,   radioP↑, 1,   toxicity↓, 1,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 163

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   AntiP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 5,   Keap1↓, 1,   NRF2↑, 1,   ROS↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 9,   NK cell↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   cardioP↑, 2,   hepatoP↑, 1,   neuroP↓, 1,   neuroP↑, 2,   toxicity∅, 1,  
Total Targets: 16

Scientific Paper Hit Count for: Inflam, inflammation
2 Centella asiatica / Gotu kola → asiaticoside
2 Honokiol
2 Hyperoside
2 Licochalcone A
2 Propolis -bee glue
1 Silver-NanoParticles
1 Astaxanthin
1 Melatonin
1 Betulinic acid
1 Crocetin
1 Eugenol
1 Paclitaxel/Taxol
1 Isobavachalcone
1 iodine
1 Isoliquiritigenin
1 Kaempferol
1 Chemotherapy
1 Resveratrol
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:953  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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