SOX4 Cancer Research Results

SOX4, SRY‐box transcription factor 4: Click to Expand ⟱
Source:
Type:
SOX4 belongs to the SOX (SRY-related HMG-box) family of transcription factors and plays a critical role in embryonic development, differentiation, and cell survival.
• In cancer, SOX4 has been implicated in processes such as epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and resistance to apoptosis.

In many cancers—including breast, colorectal, lung, ovarian, and pancreatic cancers—high SOX4 expression is generally associated with a more aggressive tumor phenotype and poorer clinical outcomes.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
4630- OLE,    Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
- in-vitro, BC, NA
Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Vim↓, Slug↓, E-cadherin↑, CSCs↓, P21↑, survivin↝, OCT4↑, Nanog↑, SOX4↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   survivin↝, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   Nanog↑, 1,   OCT4↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   Slug↓, 1,   SOX4↑, 1,   Vim↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SOX4, SRY‐box transcription factor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1060  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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