FADD Cancer Research Results

FADD, FADD: Click to Expand ⟱
Source:
Type:
FADD (Fas-associated protein with death domain) is a protein that plays a crucial role in the apoptotic signaling pathway, particularly in the process of programmed cell death. It is involved in the signaling of death receptors, such as Fas (CD95), which, when activated, can lead to apoptosis in cells.
FADD has a dual role. On one hand, it can promote apoptosis in response to certain signals, which is a mechanism that can prevent the proliferation of cancer cells. On the other hand, some cancer cells may exploit the apoptotic pathways to evade cell death, leading to tumor survival and growth.

Expression: FADD is often expressed in breast cancer cells, and its levels can vary among different subtypes.
Prognosis: High levels of FADD expression have been associated with increased apoptosis in response to certain therapies, which may correlate with better treatment outcomes. However, in some contexts, FADD can also promote cell survival, complicating its role in prognosis.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
1928- TQ,    Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

MDA↑, 1,   ROS↑, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   Casp8↑, 1,   Cyt‑c↑, 1,   DR4↑, 1,   DR5↑, 1,   FADD↑, 2,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Clinical Biomarkers ⓘ

AST↓, 1,   creat↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   hepatoP↑, 1,   RenoP↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   lipid-P↓, 1,   MDA↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: FADD, FADD
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:109  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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