antiOx Cancer Research Results

antiOx, anti-oxidant activities: Click to Expand ⟱
Source:
Type:
Various antioxidants such as Nrf2, SODs, catalase, GPxs, PRDXs, and GSTs are altered in different cancers and have been linked to prognosis. Their overexpression can correlate with aggressive tumor behavior and resistance to treatment in many contexts.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1594- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF-7
TNF-α↓, NF-kB↓, antiOx↑, TumCP↓,
4407- AgNPs,    Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231)
- in-vitro, BC, MDA-MB-231
antiOx↑, TumCG↓,
4364- AgNPs,    Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties
- in-vitro, BC, MCF-7
TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,
4541- AgNPs,  RosA,    Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities
- in-vitro, Nor, WI38 - in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1
*antiOx↑, TumCD↓, selectivity↑,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
1999- Api,  doxoR,    Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation
- in-vitro, Nor, NRK52E - in-vitro, Nor, MPC5 - in-vitro, BC, 4T1 - in-vivo, NA, NA
neuroP↑, ChemoSen∅, RenoP↑, selectivity↑, chemoP↑, ROS↑, *ROS∅, *antiOx↑, *toxicity↓,
4819- ASTX,    Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway
- in-vitro, BC, MCF-7
antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,
4818- ASTX,  MEL,    Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
5899- CAR,  TV,    Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
eff↑, selectivity↑, BioAv↝, BBB↑, *toxicity↝, *antiOx↑, COX2↓, 5LO↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
4770- CoQ10,  VitK2,    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
- in-vitro, BC, MDA-MB-231
other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, eff↑,
4633- HT,    Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells
- in-vitro, BC, NA
AntiCan↑, CSCs↓, antiOx↑, NQO1↑, TumCCA↑, ER Stress↑, Apoptosis↑, UPR↑,
4796- Lyco,    The Anti-proliferation Effects of Lycopene on Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
TumCG↓, selectivity↑, *BioAv↑, *antiOx↑, *ROS↓, Risk↓, *cardioP↑,
1779- MEL,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1669- PBG,  Chemo,    Antioxidant and anti-inflammatory effects of oral propolis in patients with breast cancer treated with chemotherapy: a Randomized controlled trial
- Trial, BC, NA
antiOx↑, Inflam↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
4473- SeNPs,    Anti-cancerous effect and biological evaluation of green synthesized Selenium nanoparticles on MCF-7 breast cancer and HUVEC cell lines
- in-vitro, BC, MCF-7 - in-vitro, Nor, HUVECs
AntiCan↑, selectivity↓, *Bacteria↓, *antiOx↑, *toxicity↓, ROS↑, tumCV↓,
1461- SFN,    Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives
- Review, BC, NA
TumCP↓, Apoptosis↑, TumCCA↑, antiOx↑,
3292- SIL,  Fe,    Anti-tumor activity of silymarin nanoliposomes in combination with iron: In vitro and in vivo study
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
*antiOx↑, ROS↑, OS↑, Weight↑, TumVol↓, eff↑, Fenton↑,
4538- TQ,    Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, H2O2↓, Catalase↑, SOD↑, GSH↑, PRNP↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, chemoPv↑, ROS↓,

Showing Research Papers: 1 to 23 of 23

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 23

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 8,   Catalase↑, 2,   Fenton↑, 1,   Ferroptosis↑, 1,   GCLM↑, 1,   GPx↑, 1,   GSH↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NQO1↑, 2,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 8,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   FASN↑, 1,   FDG↓, 1,   GlutMet↓, 1,   PDH↑, 1,   PFK↓, 1,   POLD1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 5,   BAX↑, 1,   BAX⇅, 1,   Bcl-2↓, 4,   Casp3↑, 2,   Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 2,   FADD↑, 1,   Ferroptosis↑, 1,   MAPK↑, 1,   MOMP↓, 1,   TumCD↓, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   GRP78/BiP?, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   BNIP3↑, 1,   p62↓, 1,   SESN2↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

CD24↓, 1,   CSCs↓, 3,   EMT↓, 1,   ERK↓, 1,   FOXO4↓, 1,   IGF-1↓, 2,   mTOR↓, 2,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 3,  

Migration ⓘ

5LO↓, 1,   Akt2↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 2,   PRNP↑, 1,   Slug↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 5,   TumMeta↓, 3,   Vim?, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ECM/TCF↓, 1,   EGFR↓, 1,   EGR4↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   NK cell↑, 1,   PD-1↓, 1,   PD-L1↓, 1,   Th1 response↑, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 3,   ChemoSen∅, 1,   Dose↓, 1,   Dose↝, 1,   Dose∅, 1,   eff↑, 7,   Half-Life↓, 1,   RadioS↑, 1,   selectivity↓, 1,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AST↓, 1,   creat↓, 1,   CRP↓, 1,   EGFR↓, 1,   IL6↓, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   chemoP↑, 2,   chemoPv↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 2,   Risk↓, 3,   TumVol↓, 2,   Weight↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 141

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 15,   GSH↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 4,   ROS∅, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   GlucoseCon↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,   other↝, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 3,   Inflam↑, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   ChAT↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   BioAv↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cardioP↑, 3,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 2,   toxicity↝, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 35

Scientific Paper Hit Count for: antiOx, anti-oxidant activities
4 Silver-NanoParticles
3 Astaxanthin
2 Melatonin
2 Carvacrol
2 Resveratrol
1 Citric Acid
1 Rosmarinic acid
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 doxorubicin
1 Betulinic acid
1 Thymol-Thymus vulgaris
1 Coenzyme Q10
1 Vitamin K2
1 HydroxyTyrosol
1 Lycopene
1 Propolis -bee glue
1 Chemotherapy
1 Selenium NanoParticles
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Iron
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1103  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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