LC3B-II Cancer Research Results

LC3B-II, LC3B-II: Click to Expand ⟱
Source:
Type:
LC3B-II is a lipidated form of LC3B that is widely used as a marker for autophagy.

-Several studies have reported that higher levels of LC3B-II correlate with more aggressive tumor behavior.
-Prognostic Implication: Increased LC3B-II expression is often associated with poorer prognosis, including reduced overall survival and disease‐free survival. This may reflect a role for autophagy in tumor cell survival under stress.

-Dual Role of Autophagy: Autophagy (and therefore LC3B-II expression) may act as both a tumor suppressor and a tumor promoter depending on the tumor type, stage, and microenvironment.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↓, 1,   MMP↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   ECAR↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 3,   LDHA↓, 2,   NAD↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Autophagy & Lysosomes ⓘ

LC3B-II↑, 2,   TumAuto↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 1,   CSCs↓, 1,   mTOR↓, 2,   TumCG↑, 1,  

Migration ⓘ

MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 2,   selectivity↑, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LC3B-II, LC3B-II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1208  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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