CYP1B1 Cancer Research Results
CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1: Click to Expand ⟱
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CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a xenobiotic- and hormone-metabolizing enzyme involved in oxidative metabolism, particularly of estrogens and procarcinogens.
-overexpressed in cancer, with poor prognosis
-A striking feature of CYP1B1 is its consistent overexpression in many tumors with minimal expression in adjacent normal tissue.
CYP1B1 overactivity contributes to cancer by:
-Increasing DNA damage burden
-Promoting genomic instability
-Supporting hormone-driven proliferation
-Modulating local redox balance (Generates reactive oxygen species (ROS))
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BC, Breast Cancer: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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in-vitro, |
BC, |
MDA-MB-468 |
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in-vitro, |
AML, |
JK |
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UHRF1↓, DNMT1↓, DNMT3A↓, DNMTs↓, HDAC1↓, HDAC4↓, HDAC↓, DLC1↑, PPARγ↑, FOXO↑, TET2↑, CYP1B1↑, G9a↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Core Metabolism/Glycolysis ⓘ
PPARγ↑, 1,
DNA Damage & Repair ⓘ
CYP1B1↑, 1, DNMT1↓, 1, DNMT3A↓, 1, DNMTs↓, 1, G9a↓, 1, UHRF1↓, 1,
Proliferation, Differentiation & Cell State ⓘ
FOXO↑, 1, HDAC↓, 1, HDAC1↓, 1, HDAC4↓, 1,
Migration ⓘ
DLC1↑, 1,
Drug Metabolism & Resistance ⓘ
TET2↑, 1,
Total Targets: 13
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:4 Cells:% prod#:% Target#:1345 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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