Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
Source:
Type:
The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
388- AgNPs,    Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells
- in-vitro, BC, MCF-7
ROS↑, Casp3↑, BAX↑, P53↑, Casp↑, Cyt‑c↑, MMP↓, DNAdam↑, Bcl-2↓, BAX↑,
5721- BF,    Bufalin Suppresses Triple-Negative Breast Cancer Stem Cell Growth by Inhibiting the Wnt/β-Catenin Signaling Pathway
- in-vitro, BC, NA
CSCs↓, TumCCA↑, cMyc↓, cycD1/CCND1↓, CDK4↓, MMP↓, Casp↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, SOX2↓, Wnt↓, β-catenin/ZEB1↓, EGFR↓,
5903- CAR,  TV,    Combined Cytotoxic Effects of Carvacrol-Based Essential Oil Formulations
- in-vitro, BC, MDA-MB-231
BioAv↑, MPT↑, ROS↑, Casp↑, eff↑, PI3K↓, Akt↓, TumCCA↑, Apoptosis↑, Cyt‑c↑, cl‑PARP↑, MPT↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
856- Gra,    https://pubmed.ncbi.nlm.nih.gov/33048613/
- in-vitro, BC, MCF-7
TumCCA↑, ROS↑, Casp↑,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
1992- PTL,    Parthenolide induces ROS-dependent cell death in human gastric cancer cell
- in-vitro, BC, MGC803
TumCCA↑, Casp↑, Apoptosis↑, Necroptosis↑, RIP1↓, RIP3↑, MLKL↑, ROS↑, eff↓,
2129- TQ,  doxoR,    Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
- in-vitro, BC, MCF-7
ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1↓, BNIP3↓,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 6,   i-ROS?, 1,  

Mitochondria & Bioenergetics ⓘ

MMP?, 1,   MMP↓, 3,   MPT↑, 2,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   HK2↓, 1,   PDK1↓, 2,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↑, 5,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 9,   Casp3↑, 2,   Casp8↑, 1,   Cyt‑c↑, 3,   MLKL↑, 1,   Necroptosis↑, 1,   RIP1↓, 1,   TRAIL↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 2,   DNArepair↓, 1,   P53↑, 2,   cl‑PARP↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   HDAC↓, 1,   mTOR⇅, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PTEN↑, 2,   SOX2↓, 1,   Wnt↓, 1,  

Migration ⓘ

RIP3↑, 1,   TSC1↑, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose∅, 1,   eff↓, 2,   eff↑, 2,   selectivity↑, 2,   TET2↑, 1,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,  
Total Targets: 60

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS∅, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life∅, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Casp, caspase
1 Silver-NanoParticles
1 Bufalin/Huachansu
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Ellagic acid
1 Graviola
1 Phenylbutyrate
1 Parthenolide
1 Thymoquinone
1 doxorubicin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:443  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page