Cdh1 is the gene name, while E-cadherin is the protein product of that gene.
Cdh1 is the gene that encodes E-cadherin, which is a type of cadherin, a family of proteins involved in cell-cell adhesion. E-cadherin plays a crucial role in maintaining the structure and integrity of tissues by facilitating adhesion between epithelial cells. It is particularly important in the context of development and in the maintenance of epithelial tissue architecture.
Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC).
In general, reduced or lost expression of E-cadherin (CDH1) is often associated with more aggressive tumor behavior, increased invasiveness, and poorer prognosis across various cancer types.
|