eIF2α Cancer Research Results

eIF2α, Eukaryotic translation initiation factor 2: Click to Expand ⟱
Source:
Type:
The phosphorylation of eIF2α is carried out by a family of four kinases, PERK (PKR-like ER kinase), PKR (protein kinase double-stranded RNA-dependent), GCN2 (general control non-derepressible-2), and HRI (heme-regulated inhibitor).
Eukaryotic translation initiation factor 2 alpha (eIF2α) is a critical protein involved in the initiation of protein synthesis in eukaryotic cells. It plays a key role in regulating translation in response to various cellular stresses, including nutrient deprivation, oxidative stress, and viral infection. The phosphorylation status of eIF2α is particularly important, as it can influence cell survival, apoptosis, and the overall stress response.

The phosphorylation status of eIF2α can have significant prognostic implications in cancer. Elevated levels of phosphorylated eIF2α are often associated with poor prognosis in several cancer types, as they may indicate a tumor's ability to adapt to stress and survive in unfavorable conditions.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1360- Ash,  immuno,    Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer
- in-vitro, Lung, H1650 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP/DDIT3↑, p‑eIF2α↑, ICD↑, eff↑,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1 / PDPK1↓, PDK1 / PDPK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
5190- dietMet,    Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
p‑eIF2α↑, ATF4↑, SESN2↑, TumCCA↑, Apoptosis↑, other↑,
4506- GLA,    A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells
- in-vitro, BC, BT474
Apoptosis↓, Ca+2↑, MMP↓, p‑eIF2α↑, CHOP/DDIT3↑, ER Stress↑, ROS↑,
2880- HNK,    Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vivo, NA, NA
tumCV↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, TumMeta↓, p‑eIF2α↑,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

EDEM↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ICD↑, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   ECAR↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PDK1 / PDPK1↓, 1,   p‑PDK1 / PDPK1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 3,   BAD↑, 1,   Bak↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   cl‑Casp3↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 1,   p‑eIF2α↑, 5,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP90↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   SESN2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   GADD45A↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   STAT3↓, 1,   TOP1↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 2,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 2,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↑, 2,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-L1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↑, 1,  
Total Targets: 61

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: eIF2α, Eukaryotic translation initiation factor 2
1 Ashwagandha(Withaferin A)
1 immunotherapy
1 Betulinic acid
1 diet Methionine-Restricted Diet
1 γ-linolenic acid (Borage Oil)
1 Honokiol
1 Lemongrass Extract/Citral
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:509  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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