MET Cancer Research Results

MET, mesenchymal-epithelial-transition: Click to Expand ⟱

Source:

Type:

Mesenchymal-epithelial transition (MET) is a process that is closely related to its counterpart, epithelial-mesenchymal transition (EMT). While EMT is a process by which epithelial cells acquire mesenchymal characteristics, MET is the reverse process, where mesenchymal cells gain epithelial properties.
MET is an important process that can contribute to the development and progression of tumors. During MET, cancer cells can regain their epithelial characteristics, such as cell polarity and adhesion, which can lead to the formation of more organized and differentiated tumor structures.
Mesenchymal markers Vimentin (VIM), SNAIL, SLUG, and ZEB1.

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

800-

GAR,

Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

NA,

xenograft mouse model where garcinol was found to inhibit NF-κB, miRNAs, vimentin, and nuclear β-catenin

EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1, Let-7↑, 1,

Migration ⓘ

E-cadherin↑, 1, MET↑, 1, miR-200c↑, 1, Vim↓, 1, Zeb1↓, 1, ZEB2↑, 1, p‑β-catenin/ZEB1↓, 1,

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: MET, mesenchymal-epithelial-transition

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells