DLC1 Cancer Research Results

DLC1, deleted in liver cancer 1: Click to Expand ⟱
Source:
Type: tumor suppressor gene
DLC1, or deleted in liver cancer 1, is a tumor suppressor gene that is frequently lost or mutated in HCC.
DLC1 is a gene that encodes a protein called Rho GTPase-activating protein 54 (RhoGAP54), which plays a role in regulating cell growth and division.

DLC1 has been correlated with poor prognosis. Low levels of DLC1 expression are often associated with increased tumor size, higher rates of metastasis, and shorter overall survival rates. Conversely, higher expression levels of DLC1 may indicate a better prognosis and could be linked to a more favorable response to treatment.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
417- CUR,    Curcumin inhibits the growth of triple‐negative breast cancer cells by silencing EZH2 and restoring DLC1 expression
- vitro+vivo, BC, MCF-7 - vitro+vivo, BC, MDA-MB-231 - vitro+vivo, BC, MDA-MB-468
EZH2↓, DLC1↑, cycA1/CCNA1↓, CDK1↓, Bcl-2↓, Casp9↑, DLC1↑,
3426- TQ,    Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
- in-vitro, BC, MDA-MB-468 - in-vitro, AML, JK
UHRF1↓, DNMT1↓, DNMT3A↓, DNMTs↓, HDAC1↓, HDAC4↓, HDAC↓, DLC1↑, PPARγ↑, FOXO↑, TET2↑, CYP1B1↑, G9a↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PPARγ↑, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   Casp9↑, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,  

DNA Damage & Repair ⓘ

CYP1B1↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   G9a↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   cycA1/CCNA1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC4↓, 1,  

Migration ⓘ

DLC1↑, 3,  

Drug Metabolism & Resistance ⓘ

TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DLC1, deleted in liver cancer 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:652  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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